Species Differences in Pharmacokinetics and Drug Teratogenesis

By Nau, Heinz

Book Id: WPLBN0000160155
Format Type: PDF eBook:
File Size: 1.22 MB
Reproduction Date: 2005

Title:	Species Differences in Pharmacokinetics and Drug Teratogenesis
Author:	Nau, Heinz
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago Nau, B. H. (n.d.). Species Differences in Pharmacokinetics and Drug Teratogenesis. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: The extrapolation of teratogenicity studies of drugs or chemicals from one animal species to another, in particular from experimental animals to man, remains to be very problematic (1-3). Great species differences, largely unexplained up to now, are the rule lather than the exception. Established human teratogens such as thalidomide, trimethadione, lithium, and warfarin have induced a poor teratogenic response in rats. On the other hand, nonhuman primates, which closely parallel the human response with regard to the teratogenicity of thalidomide, norethindrone, testosterone, diethylstilbestrol and methylmercury (I), fail to respond to methotrexate, a potent human teratogen (4). While all human teratogens (except the coumarin anticoagulants) were shown to be teratogenic in at least one animal species, it is difficult to state at this time which animal species is to be preferred in risk assessment studies. It appears, however, that the rabbit and, particularly, the monkey offer greater predictability of the human situation than other species (1,5).