An Approach to the Determination of the Relative Potencies of Chemical Agents during the Stages of Initiation and Promotion in Multistage Hepatocarcinogenesis in the Rat

By Pitot, Henry C.

Book Id: WPLBN0000183396
Format Type: PDF eBook:
File Size: 0.5 MB
Reproduction Date: 2005

Title:	An Approach to the Determination of the Relative Potencies of Chemical Agents during the Stages of Initiation and Promotion in Multistage Hepatocarcinogenesis in the Rat
Author:	Pitot, Henry C.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago C. Pito, B. H. (n.d.). An Approach to the Determination of the Relative Potencies of Chemical Agents during the Stages of Initiation and Promotion in Multistage Hepatocarcinogenesis in the Rat. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: The multistage nature of carcinogenesis has now heen demonstrated in a number of histogenetic systems in several species (1-3). Implicit in such a concept is that carcinogenic agents can act principally or exclusively at one or all of the definable stages in the carcinogenic process. Thus, complete and incomplete carcinogens have been defined as agents capable of acting at all stages of carcinogenesis or only at the stage of initiation, respectively (3). Promoting agents are considered to effect only the stage of promotion, although they may simulate the action of complete carcinogens through the promotion of spontaneously or fortuitously initiated cells (3).