Multiple Stages in Radiation Carcinogenesis of Rat Skin

By Albert, Roy E.

Book Id: WPLBN0000202633
Format Type: PDF eBook:
File Size: 0.4 MB
Reproduction Date: 2005

Title:	Multiple Stages in Radiation Carcinogenesis of Rat Skin
Author:	Albert, Roy E.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago E. Alber, B. R. (n.d.). Multiple Stages in Radiation Carcinogenesis of Rat Skin. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: Rat skin exposed to ionizing radiation exhibits a variety of tumor types, including squamous carcinomas, basal cell carcinomas, sarcomas, and sebaceous cell tumors. These cancers presumably arise from cells of the appropriate type within the various tissue structures occurring in skin. Rat skin has proved to be a sensitive and reproducible system for studying the dose-response and time-response characteristics of radiation-induced epithelial cancer and for investigating how the early biological events associated with the absorption of the radiation might cause a cell to embark on the pathway to cancer (1). Basal cell carcinomas are by far the most common cancer seen in human skin. These lesions occur predominantly in white-skinned individuals who lack sufficient pigmentation for filtering out the ultraviolet component of sunlight. These cancers rarely (< 5%) metastasize beyond their local site of origin. Ultraviolet light is thought to be the causative agent of most human basal cell carci. nomas Other skin cancers occurring in human skin include squamous carcinomas and melanomas, but the causative agents associated with these cancers are gener-.