Studies of Pancreatic Carcinogenesis in Different Animal Models

By Scarpelli, Dante G.

Book Id: WPLBN0000207546
Format Type: PDF eBook:
File Size: 1.29 MB
Reproduction Date: 2005

Title:	Studies of Pancreatic Carcinogenesis in Different Animal Models
Author:	Scarpelli, Dante G.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago G. Scarpell, B. D. (n.d.). Studies of Pancreatic Carcinogenesis in Different Animal Models. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: In recent years there has been considerable progress in experimental pancreatic carcinogenesis research involving basically three rodent animal models, the rat, guinea pig and Syrian golden hamster. Initial carcinogenesis studies involved implantation of 7,12-dimethylbenzanthracene (DMBA) crystals (1) or DMBA in dextrose pellets (2) into the pancreas of Sprague-Dawley rats. Pancreatic adenocarcinomas consisting of acinar cells developed, on the average, in about 200 days following implantation. Later workers administered carcinogenic substances such as 4-hydroxyaminoquinoline- 1-oxide (4HAQO), a carcinogenic metabolite of 4-nitroquinoline-I-oxide (31, azaserine (41, and the hypolipidemic drugs, nafenopin (5) and clofibrate (6.7), and NS-(N-methyl-N-nitrosocarbamoy1)-L-ornith(iMe NCO), a methylnitrosourea amino acid (S), systemically, and induced both acinar cell adenomas and adenocarcinomas. Although the rat model has been quite useful, the pancreatic neoplasms they develop do not resemble those that constitute the most common type encountered in humans, namely ductal adenocarcinomas. In the case of the guinea pig, pancreatic adenocarcinomas were induced by the prolonged administration of N-methyl-N-nitrosourethane (MNUT) (9) in drinking water, or N-methyl-N-nitrosourea (MNU) by intragastric.