Metabolic Activation of Benzo(A)Pyrene in Sencar and Balbic Mouse Embryo Cell Cultures

By Baird, William M.

Book Id: WPLBN0000211715
Format Type: PDF eBook:
File Size: 0.5 MB
Reproduction Date: 2005

Title:	Metabolic Activation of Benzo(A)Pyrene in Sencar and Balbic Mouse Embryo Cell Cultures
Author:	Baird, William M.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago M. Bair, B. W. (n.d.). Metabolic Activation of Benzo(A)Pyrene in Sencar and Balbic Mouse Embryo Cell Cultures. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: The susceptibility of rodents to tumor induction by carcinogenic chemicals depends on both the species and strain of rodent as well as on the particular type of carcinogen and the route of administration. The two-stage initiation-promotion protocol in mouse skin has been used for over 40 years as an assay for detecting tumor initiators and promoters (1). The speed and sensitivity of this assay were greatly increased by Boutwell and co-workers by breeding strains selected for susceptibility to initiation by 7,12-dimethylbenz(a)- anthracene (DMBA) and promotion by croton oil or its most active component, 12-0-tetradecanoylphorbol-13- acetate (TPA) (1,2). The SENCAR mice developed by this procedure are much more susceptible to tumor induction by this protocol than other mice such as BALBi c mice (3).