Chromatographic Modeling of the Release of Particle-Adsorbed Molecules into Synthetic Alveolar Surfactant

By Sehner, Shelley S.

Book Id: WPLBN0000216927
Format Type: PDF eBook:
File Size: 0.6 MB
Reproduction Date: 2005

Title:	Chromatographic Modeling of the Release of Particle-Adsorbed Molecules into Synthetic Alveolar Surfactant
Author:	Sehner, Shelley S.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago S. Sehne, B. S. (n.d.). Chromatographic Modeling of the Release of Particle-Adsorbed Molecules into Synthetic Alveolar Surfactant. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: Respiration and alveolar deposition of carbonaceous particle-environmental agent complexes present the scenario for desorption of the surface-adsorbed molecules into regions of the lung not normally exposed to organic toxicants. The change in free energy when a particle-bound adsorbate is released into the surfactant-rich fluid found in the alveolar region of the lung will determine equilibrium concentrations of the adsorbate in the adsorbed and solution phases. If it is assumed that entropy contributions are small, enthalpy and bioavailability may be related in a dosedependent manner. Chromatography is a useful tool to model the dynamic equilibrium of desorption of complexes typically formed by combustion processes.