Environmental Health Perspectives, Vol. 54, Pp. 171-174, 1984 : Urinary Metallothionein as an Indicator of Cadmium Body Burden and of Cadmium-Induced Nephrotoxicity

By Shaikh, Zahir A.

Book Id: WPLBN0000216956
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Reproduction Date: 2005

Title:	Environmental Health Perspectives, Vol. 54, Pp. 171-174, 1984 : Urinary Metallothionein as an Indicator of Cadmium Body Burden and of Cadmium-Induced Nephrotoxicity
Author:	Shaikh, Zahir A.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago A. Shaik, B. Z. (n.d.). Environmental Health Perspectives, Vol. 54, Pp. 171-174, 1984 : Urinary Metallothionein as an Indicator of Cadmium Body Burden and of Cadmium-Induced Nephrotoxicity. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: The biological function of metallothionein (MT) remains unclear. However, it appears that in chronic cadmium (Cd) exposure the protein is induced in liver, kidney and other tissues and is responsible for sequestration of the metal. The metal-protein complex is synthesized on free polysomes and, therefore, remains largely intracellular. Nevertheless, small amounts of Cd hound to MT-like protein have been detected in plasma of animals injected with Cd (13).S tudies by Tohyama and Shaikh (3) and by others (4) have confirmed the existence of MT in plasma by immunological methods. The circulating Cd-MT is efficiently filtered and taken up by the kidneys. If the concentration of Cd-MT is increased by experimental injection, the proximal renal tubular epithelium is damaged, resembling very much the pathology seen after chronic Cd administration (5-7). The filtered Cd-MT is, however, not completely reabsorbed and low concentrations of the protein are detectable in urine (2,8,9).