Assessing the Effects of Metabolism of Environmental Agents on Cancer Tumor Development by a Two-Stage Model of Carcinogenesis

By Singh, Karan P.

Book Id: WPLBN0000222479
Format Type: PDF eBook:
File Size: 0.5 MB
Reproduction Date: 2005

Title:	Assessing the Effects of Metabolism of Environmental Agents on Cancer Tumor Development by a Two-Stage Model of Carcinogenesis
Author:	Singh, Karan P.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago P. Sing, B. K. (n.d.). Assessing the Effects of Metabolism of Environmental Agents on Cancer Tumor Development by a Two-Stage Model of Carcinogenesis. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: In assessing effects of environmental agents on cancer development, it is important to note that the biological dose inside the cell is quite different from the exposure dose, and it is the biological dose that is directly responsible for cancer development. For example, Hoel, Kaplan, and Anderson (1) have shown that it is not the exposed dose but the DNA adduct of agents that gives a linear dose-response curve for small doses. By using Michaelis-Menten kinetics, Van Ryzin and Rai (2) and Van Ryzin (3) have shown that for the Weibull model, the one hit model, the multistage model, and the approximate multihit model, the nonlinear kinetics of metabolism of carcinogens have significant impact on doseresponse relationships in risk assessment. Further, as shown by Van Ryzin (41, in risk assessment, different models give very different results.