Phthalate Esters as Peroxisome Proliferator Carcinogens

By Warren, John R.

Book Id: WPLBN0000020124
Format Type: PDF eBook:
File Size: 0.7 MB
Reproduction Date: 2005

Title:	Phthalate Esters as Peroxisome Proliferator Carcinogens
Author:	Warren, John R.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago R. Warre, B. J. (n.d.). Phthalate Esters as Peroxisome Proliferator Carcinogens. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: A xenobiotic which induces the roliferation of roxi..omcs in liver cells is tlcsignaretl a peroxiiome membrane-limited cytoplasmic organelles which functionally have been implicated in gluconeogenesis, lipid metabolism, and the detoxification of H202. The hypolipidemic agent clofibrate was the first xenobiotic to be identified as a peroxisome proliferator (1 2). Subsequently a large number of other xenobiotics have been discovered to be peroxisome proliferators, including structural analogs of clofibrate (nafenopin, methyl cofenapate, SaH-42, 348, and gemfibrozil), hypolipidemic drugs structurally unrelated to clofibrate (tibric acid, Wy-14,643, BR-9311, and a group of miscellaneous compounds which were not developed for pharmacological utilization as hypolipidemic drugs but were incidentally discovered to express activity as peroxisomeproliferators (3,4). Theindustrial plasticizer di(2-ethylhexyl) phthalate (DEHP) and related plasticizers, including di(2-ethylhexyl) adipate, are important members of the miscellaneous peroxisome proliferators group (Fig. 1).