Liposomes in Silicosis Investigations

By Hasirci, V. N.

Book Id: WPLBN0000070868
Format Type: PDF eBook:
File Size: 0.8 MB
Reproduction Date: 2005

Title:	Liposomes in Silicosis Investigations
Author:	Hasirci, V. N.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago N. Hasirc, B. V. (n.d.). Liposomes in Silicosis Investigations. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: It has long been recognized that silica dust, when inhaled, is fibrogenic in man and experimental animals and that it can cause silicosis. It is not known how fibrosis is initiated. Theories on the mechanism of silicosis formation include: adsorption of foreign ions or molecules onto the surfaces of particles (1, 20, 31, damage caused by hard and sharp surfaces (I), progressive injury by the charge of the disrupted surface silica molecules (Piezoelectric Theory) i4), and a solubility theory which states that the damage is caused by monosilicic acid liberated by the dissolution of silica (51. Although the in vivo evidence is scanty, in vitro and in situ experiments produced results implying that silicic acid might be the toxic compound. Even if silicie acid is accepted as the toxic species, its state that causes the damage is not certain There are reports about colloidal silica (26) polymeric silicic acid (6) or monosilicic acid (7l being the cytotoxic species.