Overview of Phthalate Ester Pharmacokinetics in Mammalian Species

By Kluwe, William M.

Book Id: WPLBN0000107262
Format Type: PDF eBook:
File Size: 0.4 MB
Reproduction Date: 2005

Title:	Overview of Phthalate Ester Pharmacokinetics in Mammalian Species
Author:	Kluwe, William M.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago M. Kluw, B. W. (n.d.). Overview of Phthalate Ester Pharmacokinetics in Mammalian Species. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Introduction: It is the intent of this paper to furnish readers with a general background in phthalate ester pharmacokinetics, with emphasis on absorption, distribution, metabolism and excretion in several mammalian species. Subsequent papers in these proceedings address the absorption and metabolism of specific phthalates in more detail than is contained herein. The greatest amount of data, by far, has been collected on di(2-ethylhexyl) phthalate (DEHP), the most commonly used of the poly(viny1 chloride) (PVC) plasticizers. There seem to be sufficient similarities in some pharmacokinetic parameters of the compounds studied to date, however, to permit inferences to be drawn of the pharmacokinetics of dialkyl phthalate esters in general. Attempts to correlate similarities in pharmacokinetics to a generic pattern of toxicity for dialkyl phthalates await elucidation of probable mechanisms of toxic action.