World Health Organization : Year 1989 ; The Special Programme for Research and Training in Tropical Diseases Iver Trials, Filariasis 89.5: Clinical and Field Trials of Ivermectin for Lymphatic Filariasis Report of an Informal Consultation

By World Health Organization

Book Id: WPLBN0000210040
Format Type: PDF eBook
File Size: 0.5 MB
Reproduction Date: 2005

Title:	World Health Organization : Year 1989 ; The Special Programme for Research and Training in Tropical Diseases Iver Trials, Filariasis 89.5: Clinical and Field Trials of Ivermectin for Lymphatic Filariasis Report of an Informal Consultation
Author:	World Health Organization
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago Organization, W. H. (n.d.). World Health Organization : Year 1989 ; The Special Programme for Research and Training in Tropical Diseases Iver Trials, Filariasis 89.5. Retrieved from https://self.gutenberg.org/

Description
Medical Reference Publication

Excerpt
1. PURPOSE OF THE INFORMAL CONSULTATION The objectives of the Informal Consultation were to review the information becoming available from the present Phase I1 trials and plan what further optimal dose finding and interval studies should be done; develop outline protocols for clinical trials of ivermectin for treatment of clinical disease; outline approaches for field trials of ivermectin for prevention of clinical disease: outline strategies for community trials for reduction of transmission; and examine the need for field site preparaelon and training needs for these trials.

Table of Contents
CONTENTS 1. PURPOSE OF THE INFORMAL CONSULTATION . . . . . . 2 ' G . 2 . EXPERIENCE WITH IVERMECTIN IN LYMPHATIC FILARIASIS . 'o. l,lap' . 2 3. THE TYPES OF STUDIES TO EVALUATE IVERMECTIN USEFULNESS IN LYMPHATIC FILARIASIS . . . . . . . . . . . . . . . . . 3 3.1 Factors in the Pathogenesis of Lymphatic Fllariasis Important to the Study Design . . . . . . . . . . . . . . . . . 3 3.2 The Series of Studies . . . . . . . . . . . . . . , . . . . . . 4 4 . DRUG EFFECTS ON MF LEVELS IN INDIVIDUALS . . . . . . . . . . . . . . 4 5 . DRUG EFFECTS FOR TREATMENT OF ACUTE CLINICAL DISEASE . . . . . . . . 5 5.1 Acute Adanolpphangitis . . . . . . . . . . . . . . . . . . . . ' 5 5.2 Tropical Pulmonary Eosinophilia (TPE) . . . . . . . . . . . . . 5 6. DRUG EFFECTS ON PREVENTION OF CLINICAL DISEASE . . . . . . . . . . . 6 7. DRUG EFFECTS ON REDUCTION OF TRANSMISSION IN COMMUNITIES . . . . . . 7 7.1 Community Randomised Trials . . . . . . . . . . . . . . . . . . 7 7.2 Possible Demonstration Areas where Elimination of Transmission may be Possible . . . . . . . . . . . . . . . . . . 9 8. PROPOSED TIME LINE . . . . . . , , . . . . . . . . . . . . . . . . . 10 9. PREPARATIONS FOR FIELD TRIALS . . . . . . . . . . . . . . . . . . . . 12 9.1 Criteria for Site Selection . . , . , . . . . . . , . . . . . . 12 9.2 Possible Sites . . . , . . . . . . . , , . . . . . . . . . . . . 12 9.3 Training Needs/Baseline Studies . . . . . , , , . . . . . . . . 12 9.k Checklist for Minimum Requirements for Field Trials of Ivermectin for Lymphatic Filariasis . . . . . . . . . . . . . . 12 10. DRAFT PROTOCOLS AVAILABLE ON REQUEST . . . . . . . . . . . . . . . . 13 11. LTST OF PARTICIPANTS . . . . . . . . . . . . . . . . . . . . . . . . 14