Cell Mediated Cytotoxicity Expressed by Lymphoid Cells from Rats with Asbestos- Induced Peritoneal Mesothelioma Towards Rat Fetal Cell

By Stevens, R. H.

Book Id: WPLBN0000231715
Format Type: PDF eBook:
File Size: 0.3 MB
Reproduction Date: 2005

Title:	Cell Mediated Cytotoxicity Expressed by Lymphoid Cells from Rats with Asbestos- Induced Peritoneal Mesothelioma Towards Rat Fetal Cell
Author:	Stevens, R. H.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago H. Steven, B. R. (n.d.). Cell Mediated Cytotoxicity Expressed by Lymphoid Cells from Rats with Asbestos- Induced Peritoneal Mesothelioma Towards Rat Fetal Cell. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: Ccll-mediated immunity (CMI) directed towards rat fetal cells was evaluated in Fischer F344 young inbred male rats having asbestos-induced peritoneal mesothelioma. The tumors were induced by exposure to Canadian ehrysotile B fibers and the CMf delineated by the injury and destruction brought about to 6- to 10-day-old primary fetal cell cultures by the so-called educated peripheral blood lymphoid-cells (PBLC) obtained from the cancer-bearing rats. A significant cytotoxicity was found to be expressed by the PBLCs, suggesting that during the development of mesothelioma, a cellular retrodiffcrcntiation occurs, thereby educating the effectors to recognize a common determinant existing in both the tumor and fetal cells. Educated PBLCs were produced from rats having endedermal tissue ranccrs (adcnacareinumas ul the small bowel, colon and pancreas) and were found lo also be eytotoxie to the fetal cultures. yet nu injury was apparently inflicted upon cultured mesothelioma target cclls by these effectors. These results suggested that the tumor education was specific and that probably a unique and different fetal component was being recognized by the effector cells obtained from the rats with lesions arising either in the mesodermal or endodermal tissue. Furthcr support for this concept was the failure of an antibody, specific to an oncofetal protein existing in cndodermal lesions, to apparently recognize any common oneogenic proteins in the mesothelioma. Preliminary studies have also been accomplished which suggests the existence of natural killing immunc responses existing to the mesatheliama target cells. These results, in contrast to other recently rcparted findings, certainly intimate that asbestos-induced mcsathclioma indeed results in host antitumor immune responses and that immune therapy along with immunodiagnosis may in acluality prove to serve an important clinical rule in the management of this form of cancer.