World Library  
Flag as Inappropriate
Email this Article

Dystrophic calcification

Article Id: WHEBN0001061554
Reproduction Date:

Title: Dystrophic calcification  
Author: World Heritage Encyclopedia
Language: English
Subject: Metastatic calcification, Inborn errors of metal metabolism, Calcinosis, Peripheral ossifying fibroma, Gorham's disease
Publisher: World Heritage Encyclopedia

Dystrophic calcification

Amyloidosis, dystrophic calcification

Dystrophic calcification (DC) is the calcification occurring in degenerated or necrotic tissue, as in hyalinized scars, degenerated foci in leiomyomas, and caseous nodules. This occurs as a reaction to tissue damage,[1] including as a consequence of medical device implantation. Dystrophic calcification can occur even if the amount of calcium in the blood is not elevated. (A systemic mineral imbalance would elevate calcium levels in the blood and all tissues and cause metastatic calcification.) Basophilic calcium salt deposits aggregate, first in the mitochondria, and progressively throughout the cell. These calcifications are an indication of previous microscopic cell injury. It occurs in areas of cell necrosis in which activated phosphatases bind calcium ions to phospholipids in the membrane.

Calcification can occur in dead or degenerated tissue.


  • Calcification in dead tissue 1
  • Calcification in degenerated tissue 2
  • See also 3
  • References 4

Calcification in dead tissue

  1. Caseous necrosis in T.B. is most common site of dystrophic calcification.
  2. Liquefactive necrosis in chronic abscesses may get calcified.
  3. Fat necrosis following acute pancreatitis or traumatic fat necrosis in breasts results in deposition of calcium soaps.
  4. Infarcts may undergo D.C.
  5. Thrombi, especially in veins, may produce phlebolithis.
  6. Haematomas in the vicinity of bones may undergo D.C.
  7. Dead parasites like schistosoma eggs may calcify.
  8. Congenital toxoplasmosis or rubella may be seen on X-ray as calcifications in the brain.

[[File:Cardiovascular calcification - Sergio Bertazzo.tif|thumbnail|right|Density-Dependent Colour Scanning Electron Micrograph SEM (DDC-SEM) of cardiovascular calcification, showing in orange calcium phosphate spherical particles (denser material) and, in green, the extracellular matrix (less dense material).[2]

Calcification in degenerated tissue

  1. Dense scars may undergo hyaline degeneration and calcification.
  2. Atheroma in aorta and coronaries frequently undergo calcification.[2][3]
  3. Cysts can show calcification.
  4. Calcinosis cutis is condition in which there are irregular nodular deposits of calcium salts in skin and subcutaneous tissue.
  5. Senile degenerative changes may be accompanied by calcification.
  6. The inherited disorder pseudoxanthoma elasticum may lead to angioid streaks with calcification of Bruch's membrane, the elastic tissue below the retinal ring.

See also


  1. ^
  2. ^ a b
  3. ^
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.