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Title: Ctn-986  
Author: World Heritage Encyclopedia
Language: English
Subject: Quercetin, List of compounds with carbon numbers 30–39
Publisher: World Heritage Encyclopedia


CAS number  Y
Jmol-3D images Image 1
Molecular formula C32H38O20
Molar mass 742.63 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)

CTN-986 is a glycoside of quercetin found in cottonseeds and cottonseed oil. In a rodent model, it displays some antidepressant-like properties and stimulation of neurogenesis in the hippocampus.[1] The neurogenesis appears to be mediated by activation of the 5-HT1A receptor.[1] Co-administration with the 5-HT1A antagonist WAY-100,635 abolished the effect.[1]


  1. ^ a b c Zhang LM, Zhang YZ, Liu YQ, Gong ZH, Zhao YM, Li YF. (2009). "CTN-986, a compound extracted from cottonseeds, increases cell proliferation in hippocampus in vivo and in cultured neural progenitor cells in vitro". Eur J Pharmacol. PMID 19374877. doi:10.1016/j.ejphar.2008.12.052. 

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