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Title: Cyclochlorotine  
Author: World Heritage Encyclopedia
Language: English
Subject: List of IARC Group 3 carcinogens
Publisher: World Heritage Encyclopedia


CAS number 12663-46-6 YesY
PubChem 25565
ChemSpider 28426727 N
KEGG C19379 YesY
Jmol-3D images Image 1
Molecular formula C24H31Cl2N5O7
Molar mass 572.44 g mol−1
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cyclochlorotine[1] (CC) is a secondary metabolite of the fungus Penicillium islandicum[2] that causes hepatic necrosis and has carcinogenic properties.[3] It is listed as an IARC Group 3 carcinogen.

Chemically, it is a chlorinated macrocyclic pentapeptide derived from the amino acids 3-phenyl-β-alanine, serine, dichloroproline, and aminobutyric acid.[4]

Although tributyltin (TBT) was recently found to induce apoptosis in different immune cells.[5]


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