World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0012099822
Reproduction Date:

Title: Dopexamine  
Author: World Heritage Encyclopedia
Language: English
Subject: Octopamine, Fencamine, 3,4-Dimethylmethcathinone, 3-Fluoromethcathinone, 4-Fluoromethamphetamine
Collection: Beta1-Adrenergic Agonists, Catecholamines, Dopamine Agonists, Inotropic Agents
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
CAS Registry Number  YesY
ATC code C01
PubChem CID:
ChemSpider  YesY
Chemical data
Formula C22H32N2O2
Molecular mass 429.43 g/mol

Dopexamine is a synthetic analogue of dopamine. Despite this, it is a β1 and β2-adrenergic receptor agonist.[1] Its action at dopamine receptor D1 mediates relaxation of vascular smooth muscle in renal, mesenteric, cerebral and coronary arteries. Mild action at D2 receptors decreases noradrenaline release.[2]

Use in sepsis has been proposed.[3]

It is used as an inotropic agent in cardiac failure.[4] Side effects include arrhythmia, tremor, angina and flushing.


Dopexamine synthesis:[5]

Condensation of the adipic acid derivative 1 with phenethylamine in the presence of Carbonyldiimidazole affords bis-adipic acid amide 2. The synthesis is completed by reduction of the carbonyl groups with diborane followed by demethylation of the aromatic methoxy groups with hydrogen bromide to afford dopexamine.


  1. ^
  2. ^
  3. ^
  4. ^
  5. ^ J. B. Farmer, F. Ince, R. A. Brown, and J. Dixon, U.S. Patent 5,013,760 via Chem. Abstr., 99: 53,408q (1983). Anon. Drugs of the Future, 10, 628 (1985).

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.