End-diastolic volume

In cardiovascular physiology, end-diastolic volume (EDV) is the volume of blood in the right and/or left ventricle at end load or filling in (diastole) or the amount of blood in the ventricles just before systole. Because greater EDVs cause greater distention of the ventricle, 'EDV is often used synonymously with preload, which refers to the length of the sarcomeres in cardiac muscle prior to contraction (systole). An increase in EDV increases the preload on the heart and, through the Frank-Starling mechanism of the heart, increases the amount of blood ejected from the ventricle during systole (stroke volume).

Parameters affecting EDV 1
Sample values 2
See also 3
References 4

Parameters affecting EDV

Because nearly two-thirds of the blood in the systemic circulation is stored in the venous system, end-diastolic volume is closely related to venous compliance.

Increasing venous compliance elevates the capacitance of the veins, reducing venous return and therefore end-diastolic volume.

Decreasing venous compliance has the opposite effect. For example, activation of the baroreceptor reflex (occurring, for instance, in acute hemorrhage) causes vasoconstriction, which decreases venous compliance, improves venous return, and therefore increases end-diastolic volume.

Sample values

The values below are for the left ventricle:

Measure	Typical value	Normal range
end-diastolic volume (EDV)	120 mL^[1]	65–240 mL^[1]
end-systolic volume (ESV)	50 mL^[1]	16–143 mL^[1]
stroke volume (SV)	70 mL	55–100 mL
ejection fraction (E_f)	58%	55–70%^[2]
heart rate (HR)	75 bpm	60–100 bpm^[3]
cardiac output (CO)	5.25 L/minute	4.0–8.0 L/min^[4]

The right ventricular end-diastolic volume (RVEDV) ranges between 100 and 160 mL.^[4] The right ventricular end-diastolic volume index (RVEDVI) is calculated by RVEDV/BSA and ranges between 60 and 100 mL/m².^[4]

References

^ ^a ^b ^c ^d Schlosser, Thomas; Pagonidis, Konstantin; Herborn, Christoph U.; Hunold, Peter; Waltering, Kai-Uwe; Lauenstein, Thomas C.; Barkhausen, Jörg (2005). "Assessment of Left Ventricular Parameters Using 16-MDCT and New Software for Endocardial and Epicardial Border Delineation". Values:
- End-diastolic volume (left ventricular) – average 118 and a range of 68 – 239mL and
- End-systolic volume (left ventricular) – average 50.1 and range, 16 – 143 mL:
- Also, ejection fraction was estimated in this study to be average 59.9% ± 14.4%; range, 18 – 76%, but secondary source (see above) is used in this article instead.
^ O'Connor, Simon (2009). Examination Medicine (The Examination). Edinburgh: Churchill Livingstone. p. 41.
^ Normal ranges for heart rate are among the narrowest limits between bradycardia and tachycardia. See the Bradycardia and Tachycardia articles for more detailed limits.
^ ^a ^b ^c Edwards Lifesciences LLC > Normal Hemodynamic Parameters – Adult 2009

Physiology of the cardiovascular system

Heart

Cardiac output	Cardiac cycle Cardiac output Heart rate Stroke volume Stroke volume End-diastolic volume End-systolic volume Afterload Preload Frank–Starling law of the heart Cardiac function curve Venous return curve Wiggers diagram Pressure volume diagram

Ultrasound	Fractional shortening = (End-diastolic dimension End-systolic dimension) / End-diastolic dimension Aortic valve area calculation Ejection fraction Cardiac index

Heart rate	Cardiac pacemaker Chronotropic (Heart rate) Dromotropic (Conduction velocity) Inotropic (Contractility) Bathmotropic (Excitability) Lusitropic (Relaxation)

Conduction	Conduction system Cardiac electrophysiology Action potential cardiac atrial ventricular Effective refractory period Pacemaker potential Electrocardiography P wave PR interval QRS complex QT interval ST segment T wave U wave Hexaxial reference system

Chamber pressure	Central venous Right atrial ventricular pulmonary artery wedge Left atrial ventricular Aortic

Other	Ventricular remodeling

Vascular system/
Hemodynamics

Blood flow	Compliance Vascular resistance Pulse Perfusion

Blood pressure	Pulse pressure Systolic Diastolic Mean arterial pressure Jugular venous pressure Portal venous pressure

Regulation of BP	Baroreflex Kinin–kallikrein system Renin–angiotensin system Vasoconstrictors Vasodilators Autoregulation Myogenic mechanism Tubuloglomerular feedback Cerebral autoregulation Paraganglia Aortic body Carotid body Glomus cell

Index of the heart

Description

Disease

Treatment	Drugs

Index of the circulatory system

Description	Arteries Veins

Disease

Treatment	Drugs

Categories

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End-diastolic volume