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George Emil Palade

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George Emil Palade

George E. Palade
Dr. George E. Palade won the Nobel Prize in 1974.
Born November 19, 1912
Iași, Romania
Died October 7, 2008(2008-10-07) (aged 95)
Del Mar, California, USA
Citizenship United States and Romania
Nationality Romanian
Fields Cell biology
Alma mater Carol Davila School of Medicine
Notable students Günter Blobel[1]
Known for Ribosomes, Rough ER
Notable awards Gairdner Foundation International Award (1967)
Nobel Prize in Physiology or Medicine (1974)
Louisa Gross Horwitz Prize (1970)
E. B. Wilson Medal (1981)
National Medal of Science (1986)

George Emil Palade (Romanian pronunciation: ; November 19, 1912 – October 8, 2008) was a Romanian-American cell biologist. He was described as "the most influential cell biologist ever";[2] in 1974 he was awarded the Nobel Prize in Physiology and Medicine, together with Albert Claude and Christian de Duve. The prize was granted for his innovations in electron microscopy and cell fractionation which together laid the foundations of modern molecular cell biology.,[2] the most notable discovery being the ribosomes of the endoplasmic reticulum – which he first described in 1955.[3]

Palade also received the U.S. National Academy of Science in 1961.

Contents

  • Biography 1
  • Research note: Palade's coworkers and approach in the 1960s 2
  • See also 3
  • References 4
  • Sources 5
  • External links 6

Biography

George Emil Palade was born on November 19, 1912 in [4]

In 1952, Palade became a naturalized citizen of the United States. He worked at the Rockefeller Institute (1958–1973), and was a professor at Yale University Medical School (1973–1990), and University of California, San Diego (1990–2008). At UCSD, Palade was Professor of Medicine in Residence (Emeritus) in the Department of Cellular & Molecular Medicine, as well as a Dean for Scientific Affairs (Emeritus), in the School of Medicine at La Jolla, California.[5]

In 1970, he was awarded the [6] related to his previous research carried out at the Rockefeller Institute for Medical Research.[7] His Nobel lecture, delivered on December 12, 1974, was entitled: "Intracellular Aspects of the Process of Protein Secretion",[8] published in 1992 by the Nobel Prize Foundation,[9] .[10] He was elected an Honorary member of the Romanian Academy in 1975. In 1988 he was also elected an Honorary Member of the American-Romanian Academy of Arts and Sciences (ARA).

Palade was the first Chairman of the Department of Cell Biology at Yale University. Presently, the Chair of Cell Biology at Yale is named the "George Palade Professorship".

At the Rockefeller Institute for Medical Research, Palade used ribosomes, mitochondria, chloroplasts, the Golgi apparatus, and others. His most important discovery was made while using an experimental strategy known as a pulse-chase analysis. In the experiment Palade and his colleagues were able to confirm an existing hypothesis that a secretory pathway exists and that the Rough ER and the Golgi apparatus function together.

He focused on endothelium, containing von Willebrand factor and various proteins) which he described together with the Swiss anatomist Ewald R. Weibel.[11]

Palade is survived by his wife Marilyn Farquhar, a cell biologist at the University of California, San Diego, and a daughter and son from his first marriage.].[12]

Research note: Palade's coworkers and approach in the 1960s

The following is a concise excerpt from Palade's Autobiography appearing in the Nobel Award documents[4]

"In the 1960s, I continued the work on the secretory process using in parallel or in succession two different approaches. The first relied exclusively on cell fractionation, and was developed in collaboration with Philip Siekevitz,

  • George Palade, Nobel Winner for Work Inspiring Modern Cell Biology, Dies at 95
  • Autobiography written in 1974 for the Nobel Prize
  • The Official Site of Louisa Gross Horwitz Prize

External links

  • Editor (2007). "Tribute to Professor George E. Palade".  
  • Singer, Manfred V (2003). "Legacy of a distinguished scientist: George E. Palade".  
  • Haulică, I (2002). "[Professor doctor George Emil Palade at 90 years of age]". Revista medico-chirurgicală a Societăţii de Medici şi Naturalişti din Iaşi ( 
  • Tartakoff, Alan M (November 2002). "George Emil Palade: charismatic virtuoso of cell biology".  
  • Motta, P M (2001). "George Emil Palade and Don Wayne Fawcett and the development of modern anatomy, histology and contemporary cell biology". Italian journal of anatomy and embryology [Archivio italiano di anatomia ed embriologia] (Italy) 106 (2 Suppl 1): XXI–XXXVIII.  
  • Farquhar, M G; Wissig S L; Palade G E (December 1999). "Glomerular permeability I. Ferritin transfer across the normal glomerular capillary wall. 1961".  
  • Raju, T N (October 1999). "The Nobel chronicles. 1974: Albert Claude (1899-1983), George Emil Palade (b 1912), and Christian Réne de Duve (b 1917)".  
  • Sabatini, D D (October 1999). "George E. Palade: charting the secretory pathway".  
  • Motta, P M (1998). "George Emil Palade and Don Wayne Fawcett and the development of modern anatomy, histology and contemporary cell biology". Italian journal of anatomy and embryology [Archivio italiano di anatomia ed embriologia] (Italy) 103 (2): 65–81.  
  • Porter, K R (July 1983). "An informal tribute to George E. Palade".  
  • Tashiro, Y (January 1975). "[Accomplishment of Drs. Albert Calude and George E. Palade and the birth of cell biology]".  
  • Magner, J W; Ritchie E H; Cahill S C (January 1975). "Current medical literature".  
  • "George E. Palade". Triangle; the Sandoz journal of medical science (Switzerland) 9 (6): 229–30. 1970.  

Sources

  1. ^ "The Palade Symposium: Celebrating Cell Biology at Its Best"
  2. ^ a b "Prof. George Palade: Nobel prize-winner whose work laid the foundations for modern molecular cell biology". The Independent. 22 October 2008. Retrieved 2011-02-09.  Archived. (Internet Archive copy)
  3. ^ Grens, Kerry (February 1, 2014). "Palade Particles, 1955". The Scientist. 
  4. ^ a b c "George E. Palade - Autobiography". Nobelprize.org. 2008-10-07. Retrieved 2011-04-03. 
  5. ^ Professor George E. Palade - web page at the University of California at San Diego, School of medicine Archived March 30, 2004 at the Wayback Machine
  6. ^ "The 1974 Nobel Prize for Medicine". Nobelprize.org. Retrieved 2011-04-03. 
  7. ^ http://www.rockefeller.edu/nobel.html
  8. ^ a b "Nobel lecture". Nobelprize.org. 1974-12-12. Retrieved 2011-04-03. 
  9. ^ The Nobel Prize Lecture of George E. Palade (Pdf 3.78 MB), (1974) The Nobel Foundation, ISBN 981-02-0791-3
  10. ^ Nobel Lectures in Physiology or Medicine Archived July 14, 2008 at the Wayback Machine
  11. ^ Weibel, ER; Palade, GE (1964). "New cytoplasmic components in arterial endothelia". J. Cell. Biol. 23: 101–112.  
  12. ^ y James D. Jamieson (November 8, 2008). "Obituary: "A tribute to George E. Palade".  
  13. ^ 2009 Nobel Prize in Chemistry, Nobel Foundation

References

See also

[13]

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