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Mmda-2

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Title: Mmda-2  
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Subject: 6-Methyl-MDA, 2,5-Dimethoxy-4-propylamphetamine, DMMDA, Dimethoxymethamphetamine, 3-Methoxy-4-methylamphetamine
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Mmda-2

MMDA-2
Systematic (IUPAC) name
1-(6-methoxy-1,3-benzodioxol-5-yl)propan-2-amine
Clinical data
Legal status
Routes Oral, Insufflated, Rectal
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
Chemical data
Formula C11H15NO3 
Mol. mass 209.24 g/mol

MMDA-2 (2-methoxy-4,5-methylenedioxyamphetamine) is a psychedelic drug of the amphetamine class.[1] It is closely related to MMDA and MDA.[1]

Alexander Shulgin was likely the first to synthesize MMDA-2.[1] In his book PiHKAL, the dose is listed as 25–50 mg, and the duration is listed as 8–12 hours.[1] Shulgin reports that MMDA-2 produces effects such as enhanced awareness, empathy, and visual facilitation and distortion, as well as some side effects like gastrointestinal upset and appetite loss.[1] He states that 30 mg is very similar to 80 mg of MDA, and also remarks that it would be impossible for anyone to have a bad experience on the drug at that dose.[1]

Scientific research has shown that MMDA-2, unlike MMDA, but similarly to 6-methyl-MDA, is only very weak at inducing the release of serotonin or dopamine,[2] and accordingly, does not produce amphetamine-appropriate responding in animals in drug discrimination studies.[3] Instead, MMDA-2 is likely to act as a pure 5-HT2 receptor agonist similarly to the DOx series of compounds, with activation of the 5-HT2A receptor conferring its psychedelic effects.[4]

MMDA-2 has been sold as a designer drug in Japan.[5]

See also

References

  1. ^ a b c d e f Ann Shulgin; Alexander Shulgin (1991). Pihkal: A Chemical Love Story. Transform Press.  
  2. ^ McKenna DJ, Guan XM, Shulgin AT (March 1991). "3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine". Pharmacology, Biochemistry, and Behavior 38 (3): 505–12.  
  3. ^ Glennon RA, Yousif M, Naiman N, Kalix P (March 1987). "Methcathinone: a new and potent amphetamine-like agent". Pharmacology, Biochemistry, and Behavior 26 (3): 547–51.  
  4. ^ Clare BW (2002). "QSAR of benzene derivatives: comparison of classical descriptors, quantum theoretic parameters and flip regression, exemplified by phenylalkylamine hallucinogens". Journal of Computer-aided Molecular Design 16 (8–9): 611–33.  
  5. ^ Min JZ, Shimizu Y, Toyo'oka T, Inagaki S, Kikura-Hanajiri R, Goda Y (October 2008). "Simultaneous determination of 11 designated hallucinogenic phenethylamines by ultra-fast liquid chromatography with fluorescence detection". Journal of Chromatography B 873 (2): 187–94.  

External links

  • Erowid - PiHKAL entry for MMDA-2
  • Isomerdesign - PiHKAL entry for MMDA-2
Phenethylamines
Amphetamines
Phentermines
Cathinones
Phenylisobutylamines
Phenylalkylpyrrolidines
Catecholamines
(and close relatives)
Miscellaneous
Drugs from PiHKAL
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