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Nodular sclerosis

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Title: Nodular sclerosis  
Author: World Heritage Encyclopedia
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Subject: Hodgkin's lymphoma, Reed–Sternberg cell, Lymphocytic leukemia, Diffuse infiltrative lymphocytosis syndrome, Primary mediastinal B-cell lymphoma
Publisher: World Heritage Encyclopedia

Nodular sclerosis

Nodular sclerosis
Nodular sclerosis. The distinct nodules on the cut surface of this lymph node strongly suggest the diagnosis.
Classification and external resources
ICD-10 C81.1
ICD-9-CM 201.5
ICD-O M9663/3-9667/3

Nodular sclerosis (or "NSHL") is a form of Hodgkin's lymphoma[1] that is the most common subtype of HL in developed countries. It affects females slightly more than males and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed-Sternberg cell (RS cells) surrounded by fibrotic collagen bands.

The British National Lymphoma Investigation further categorized NSHL based upon Reed-Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first subtype responding better to treatment. [2]


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External links

  • Illustration, at UMDNJ
  • Illustration
  • PubMed - use of Erythropoietin
  • Subtypes
  • Lymphoma Association information on nodular sclerosing

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