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Title: 2-Fluoroamphetamine  
Author: World Heritage Encyclopedia
Language: English
Subject: 2-Fluoromethamphetamine, Ortetamine, 3-Fluoroamphetamine, Caffeine, Designer drugs
Collection: Amphetamines, Designer Drugs, Fluoroarenes, Norepinephrine-Dopamine Releasing Agents, Organofluorides, Substituted Amphetamines
Publisher: World Heritage Encyclopedia


Ball-and-stick model of the 2-fluoroamphetamine molecule
Systematic (IUPAC) name
Clinical data
Legal status
CAS Registry Number  N
PubChem CID:
ChemSpider  YesY
Chemical data
Formula C9H12FN
Molecular mass 153.196 g/mol
1 gram of 2-FA

2-Fluoroamphetamine (2-FA) is a stimulant drug from the amphetamine family which has been sold as a designer drug.[1] 2-Fluoroamphetamine differs from 3- and 4-fluoroamphetamine in the position of the fluorine atom on the aromatic ring, making them positional isomers of one another. The replacement of a hydrogen atom with a fluorine atom in certain compounds to facilitate passage through the blood–brain barrier, as is desirable in central nervous system pharmaceutical agents, is a common practice due to the corresponding increase in lipophilicity granted by the substitute.[2][3]


  • Pharmacology 1
  • Toxicology 2
  • Legal Status 3
    • United States 3.1
    • China 3.2
  • See also 4
  • References 5


Anorexiant dose (amount inhibiting food intake by 50% for 2 hours, given 1 hour earlier) = 15 mg/kg (rat; p.o.).[4]

Analgesic dose (50% inhibition of response to tail-clamp) = 20 mg/kg (mouse; i.p.).[4]

Effect on blood pressure: 0.5 mg/kg (rat; i.v.) produces an increase in BP of 29 mm.[4]


LD50 (mouse; i.p.) = 100 mg/kg.[4]

Legal Status

United States

The Federal Analog Act, 21 U.S.C. § 813, is a section of the United States Controlled Substances Act, allowing any chemical "substantially similar" to an illegal drug (in Schedule I or II) to be treated as if it were also in Schedule I or II, but only if it is intended (ref 1) for human consumption. 2-FA may be considered to be an analog of amphetamine, thus falling under the Federal Analog Act.


As of October 2015 2-FA is a controlled substance in China.[5]

See also


  1. ^
  2. ^
  3. ^
  4. ^ a b c d E. Costa and S. Garattini (1970) Amphetamines and Related Compounds, p.28, New York: Raven Press.
  5. ^

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