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Title: 8-oxoguanine  
Author: World Heritage Encyclopedia
Language: English
Subject: Mutagenesis, DNA glycosylase, Base excision repair, Oxoguanine glycosylase
Publisher: World Heritage Encyclopedia


CAS number 5614-64-2 YesY
PubChem 119315
ChemSpider 106574 YesY
MeSH 8-hydroxyguanine
ChEBI CHEBI:44605 YesY
Jmol-3D images Image 2
Molecular formula C5H5N5O2
Molar mass 167.13 g mol−1
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

8-Oxoguanine (8-hydroxyguanine, 8-oxo-Gua, or OH8Gua) is one of the most common DNA lesions resulting from reactive oxygen species [2] and can result in a mismatched pairing with Adenine resulting in G to T and A to C substitutions in the genome.[3] In humans, it is primarily repaired by the DNA glycosylase OGG1. It can be caused by ionizing radiation, in connection with oxidative metabolism.


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