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Al-37350a

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Title: Al-37350a  
Author: World Heritage Encyclopedia
Language: English
Subject: 1-(2-Dimethylaminoethyl)dihydropyrano(3,2-e)indole, AL-38022A, DALT, 7,N,N-TMT, Alpha-N,N-Trimethyltryptamine
Collection: Pyrans, Serotonin Receptor Agonists, Tryptamines
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Al-37350a

AL-37350A
Systematic (IUPAC) name
(S)-(+)-1-(2-Aminopropyl)-8,9-dihydropyrano[3,2-e]indole
Clinical data
Legal status
?
Identifiers
CAS number  N
ATC code ?
PubChem
IUPHAR ligand
ChemSpider  YesY
ChEMBL  YesY
Chemical data
Formula C14H18N2O 
Mol. mass 230.305 g/mol
 N   

AL-37350A (4,5-DHP-AMT) is a tryptamine derivative which acts as a potent and selective agonist for the serotonin receptor 5-HT2A, with a Ki of 2.0 nM, and moderate selectivity over the related 5-HT2B and 5-HT2C receptors. It has been shown to have ocular hypotensive activity in animal models, suggesting it may be useful for the treament of glaucoma.[1]

See also

References

  1. ^ May JA, Chen HH, Rusinko A, Lynch VM, Sharif NA, McLaughlin MA (September 2003). "A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole". Journal of Medicinal Chemistry 46 (19): 4188–95.  


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