World Library  
Flag as Inappropriate
Email this Article

Avax Technologies

Avax Technologies
Type Public
Industry Biomedicine
Headquarters Philadelphia, Pennsylvania, USA
Key people Richard Rainey (Chairman and CEO)
Products AC Vaccine
Services Cancer vaccines
Subsidiaries Genopoietic SA

Avax Technologies, Inc (OTC Pink: AVXT) is a Philadelphia based biotechnology company whose most advanced product candidate is MVax for melanoma. MVax is a cancer vaccine that received a Special Protocol Assessment agreement with the FDA in October 2006, and subsequently began a Phase III registration clinical trial in November 2007 [1]. In previous studies, MVax demonstrated a 5-year overall survival rate (OS)of 44% and response rate of 35% (13% CR, 22% PR).[1]


  • AC Vaccine 1
    • Method 1.1
    • Product Candidates 1.2
      • MVax 1.2.1
      • LVax 1.2.2
      • OVax 1.2.3
  • Genopoietic SA 2
  • See also 3
  • Notes 4
  • External links 5

AC Vaccine


A tumor sample is removed from a patient, then treated with the hapten 2,4-Dinitrophenol. When reinjected back into the patient, the hapten will cause an enhanced immune response against the cancer cells.

Product Candidates


Started May 2007. Currently in a Phase III trial for Stage IV Melanoma.

MVax’s Phase II response rate of 35% (CR + PR) in combination with low-dose IL-2 compares favorably to the Phase II results of other melanoma cancer vaccines such as Vical’s Allovectin-7 (11% CR + PR)[2] and BioVex’s OncoVex (28% CR + PR),[3] both of which are given as stand alone therapy.

Due to the Financial crisis of 2007–2010 and recent cancer vaccine failures in other companies like Favrille and Cell Genesys, Avax has had trouble attracting investors. In an effort to conserve cash, enrollment for the Phase III trial was suspended on March 26, 2009,[4] but the trial itself is still ongoing. However on December 16, 2009, the company obtained bridge financing in the amount of $1,400,000. This will be used to conduct an interim analysis of the Phase III data for MVax. CEO John Prendergast notes: "Recent and anticipated news by companies involved with cancer vaccines and immunotherapies has resulted in renewed interest in the sector by institutional investors, larger pharma, biotechnology companies and the medical and scientific communities at large.".[5]


Started February 2006. Currently in a Phase I/II trial for NSCLC. No new patient enrollment until more funding is obtained.


Started April 2008.Currently in a Phase I/II trial for Ovarian Cancer.No new patient enrollment until more funding is obtained.

Genopoietic SA

Based in Lyon, France,Genopoietic has a GMP facility that manufactures the vaccines for Avax. The facility is certified by the French government for commercial and clinical vaccine production for the European markets.[1]

See also


  1. ^ a b "Avax fact sheet Phase II data". 
  2. ^ "Allovectin-7 Phase II data". 
  3. ^ "OncoVex Phase II data". 
  4. ^ "Enrollment Suspension". 
  5. ^ "December 16, 2009 news". 

External links

  • AVXT Facebook fan page (has a discussion about the company)
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.