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Benocyclidine (BTPC), or benzothiophenylcyclohexylpiperidine (BTCP), is a psychoactive recreational drug of the arylcyclohexylamine class. It was first described in a patent application naming Marc Caron and colleagues at Duke University in 1997.[1]
It acts as a potent and selective dopamine reuptake inhibitor (DRI) and a psychostimulant.[2][3] Unlike related compounds like phencyclidine and ketamine, benocyclidine is a pure DRI with negligible affinity for the NMDA receptor, and it therefore lacks any anticonvulsant, anesthetic, hallucinogenic, or dissociative effects.[2][3] It has been used to label the dopamine transporter.[4][5]
BCP was also used to try to find a common pharmacophore for DRI type stimulants.[6]
More recently, benocyclidine has been found in several ecstasy tablets, sold as MDMA.[7]
Ahmadi, Abbas (2014). "Synthesis and Pain Perception of New Analogues of Phencyclidine in NMRI Male Mice". Mini-Reviews in Medicinal Chemistry 14 (1): 64–71.
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