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CBX5 (gene)

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Title: CBX5 (gene)  
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Subject: Heterochromatin protein 1, HDAC9, SUV39H1, Histone deacetylase 5, HDAC4
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CBX5 (gene)

Chromobox homolog 5
Rendering based on PDB .
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; HEL25; HP1; HP1A
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene.[1][2] It is a highly conserved, non-histone protein part of the heterochromatin family.


Heterochromatin protein-1α (HP1α)[3] possesses an N-terminal chromodomain which binds to histone proteins via methylated lysine residues leading to epigenetic repression.[4] The C-terminal of this protein has a chromo shadow-domain (CSD). The CSD is responsible for the homodimerization and interaction with a variety of chromatin-associated non-histone proteins.[5]


CBX5 (gene) has been shown to interact with:

See also


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Further reading

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