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Cgs-15943

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Title: Cgs-15943  
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Subject: SCH-58261, 8-Chlorotheophylline, 8-Cyclopentyl-1,3-dimethylxanthine, Xanthine, Dimethazan
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Cgs-15943

CGS-15943
Systematic (IUPAC) name
9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
Clinical data
Legal status
  • Uncontrolled
Identifiers
CAS Registry Number  N
ATC code None
PubChem CID:
IUPHAR/BPS
ChemSpider  YesY
ChEMBL  YesY
Chemical data
Formula C13H8ClN5O
Molecular mass 285.689 g/mol
 N   

CGS-15943 is a drug which acts as a potent and reasonably selective antagonist for the adenosine receptors A1 and A2A, having a Ki of 3.3nM at A2A and 21nM at A1. It was one of the first adenosine receptor antagonists discovered that is not a xanthine derivative, instead being a triazoloquinazoline.[1][2] Consequently CGS-15943 has the advantage over most xanthine derivatives that it is not a phosphodiesterase inhibitor, and so has more a specific pharmacological effects profile. It produces similar effects to caffeine in animal studies, though with higher potency.[3][4][5][6][7]

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