World Library  
Flag as Inappropriate
Email this Article

Caspase 8

Article Id: WHEBN0010030080
Reproduction Date:

Title: Caspase 8  
Author: World Heritage Encyclopedia
Language: English
Subject: Bcl-2, Fas ligand, Autoimmune lymphoproliferative syndrome, Fas receptor, FADD, BH3 interacting-domain death agonist, Caspase-9, Caspase 2, Caspase 3
Publisher: World Heritage Encyclopedia

Caspase 8

Caspase 8, apoptosis-related cysteine peptidase
PDB rendering based on 1f9e.
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Caspase 8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase 3. CASP8 orthologs [1] have been identified in numerous mammals for which complete genome data are available. These unique orthologs are also present in birds.


The CASP8 gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.[2]


Caspase 8 has been shown to interact with CFLAR,[3][4][5][6][7][8][9] PEA15,[10][11] Caspase 10,[3][12][13][14] Caspase-9,[13][14] Fas receptor,[4][12][15] Fas ligand,[3][12] Caspase 7,[13][14] NOL3,[16] BH3 interacting domain death agonist,[12][13] DEDD,[17][18][19] TRAF1,[3][20] Bcl-2,[13][21] RIPK1,[22][23][24] TNFRSF10B,[12][15] FADD,[3][6][12][23][25][26][27] BCAP31,[28] IFT57,[29] Caspase 3,[13][14] Caspase 2[13][14] and Caspase 6.[13][14][30]

Additional Photos

See also


Further reading

External links

  • The C14.009
  • The Proteolysis Map-animation
  • Medical Subject Headings (MeSH)
  • caspase-8
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.