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Caspase 8

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Title: Caspase 8  
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Subject: Bcl-2, Fas ligand, Autoimmune lymphoproliferative syndrome, Fas receptor, FADD, BH3 interacting-domain death agonist, Caspase-9, Caspase 2, Caspase 3
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Caspase 8

Caspase 8, apoptosis-related cysteine peptidase
PDB rendering based on 1f9e.
Available structures
PDB Ortholog search: RCSB
Identifiers
3.4.22.61
RNA expression pattern

Caspase 8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase 3. CASP8 orthologs [1] have been identified in numerous mammals for which complete genome data are available. These unique orthologs are also present in birds.

Description

The CASP8 gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.[2]

Interactions

Caspase 8 has been shown to interact with CFLAR,[3][4][5][6][7][8][9] PEA15,[10][11] Caspase 10,[3][12][13][14] Caspase-9,[13][14] Fas receptor,[4][12][15] Fas ligand,[3][12] Caspase 7,[13][14] NOL3,[16] BH3 interacting domain death agonist,[12][13] DEDD,[17][18][19] TRAF1,[3][20] Bcl-2,[13][21] RIPK1,[22][23][24] TNFRSF10B,[12][15] FADD,[3][6][12][23][25][26][27] BCAP31,[28] IFT57,[29] Caspase 3,[13][14] Caspase 2[13][14] and Caspase 6.[13][14][30]

Additional Photos

See also

References

Further reading

External links

  • The C14.009
  • The Proteolysis Map-animation
  • Medical Subject Headings (MeSH)
  • caspase-8
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