World Library  
Flag as Inappropriate
Email this Article

Chlorzoxazone

Article Id: WHEBN0006139870
Reproduction Date:

Title: Chlorzoxazone  
Author: World Heritage Encyclopedia
Language: English
Subject: Thiocolchicoside, Styramate, Flopropione, Lorbamate, Cyclarbamate
Collection: Benzoxazoles, Carbamates, Chloroarenes, Muscle Relaxants, Organochlorides
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Chlorzoxazone

Chlorzoxazone
Systematic (IUPAC) name
5-chloro-3H-benzooxazol-2-one
Clinical data
Trade names Parafonforte
AHFS/Drugs.com
MedlinePlus
Routes of
administration
oral
Pharmacokinetic data
Bioavailability well absorbed
Protein binding 13–18%
Metabolism hepatic
Biological half-life 1.1 hr
Excretion urine (<1%)
Identifiers
CAS Registry Number  YesY
ATC code M03
PubChem CID:
IUPHAR/BPS
DrugBank  YesY
ChemSpider  YesY
UNII  YesY
KEGG  YesY
ChEBI  YesY
ChEMBL  YesY
Chemical data
Formula C7H4ClNO2
Molecular mass 169.565 g/mol
 YesY   

Chlorzoxazone (INN) is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold under the trade names Paraflex and Muscol and in combination form as Parafon Forte, a combination of chlorzoxazone and acetaminophen (paracetamol). Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction. Used with acetaminophen it has added risk of hepatoxicity, which is why the combination is not recommended. It can also be administered for acute pain in general and for tension headache (muscle contraction headache).

Synthesis

Chlorzoxazone synthesis: Mcneilab Inc, David F Marsh. U.S. Patent 2,895,877

Chlorzoxazone, 5-chloro-2-benzoxazolione, is synthesized by a hetercyclization reaction of 2-amino-4-chlorophenol with phosgene.

References

  • D.F. Marsh, U.S. Patent 2,895,877 (1959).
  • PARAFON DSC (chlorzoxazone) tablet, Daily Med, U.S. National Library of Medicine


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.