Coenzyme M is a coenzyme required for methyl-transfer reactions in the metabolism of methanogens.[1][2] The coenzyme is an anion with the formula Template:Chem/link. It is named 2-mercaptoethanesulfonate and abbreviated HS–CoM. The cation is unimportant, but the sodium salt is most available. Mercaptoethanesulfonate contains both a thiol, which is the main site of reactivity, and a sulfonate group, which confers solubility in aqueous media.

Biochemical role

The coenzyme is the C1 donor in methanogenesis. It is converted to propyl coenzyme M-thioester, the thioether Template:Chem/link, in the penultimate step to methane formation.[3] Coenzyme M reacts with coenzyme B, 7-thioheptanoylthreoninephosphate, to give a homodisulfide, releasing methane:

Template:Chem/link + HS–CoB → Template:Chem/link + CoB–S–S–CoM

This induction is catalyzed by the enzyme methyl-coenzyme M reductase, which restricts cofactor F430 as the prosthetic group.


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