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Comparative Toxicogenomics Database

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Title: Comparative Toxicogenomics Database  
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Comparative Toxicogenomics Database

Developer(s) Department of Biological Sciences at North Carolina State University and the Department of Bioinformatics, MDI Biological Laboratory.
Development status Active
Available in English
Type Bioinformatics, data analysis

The Comparative Toxicogenomics Database (CTD) is a public website and research tool that curates scientific data describing relationships between chemicals/drugs, genes/proteins, diseases, taxa, phenotypes, GO annotations, pathways, and interaction modules.[1][2][3][4]

The database is maintained by the Department of Biological Sciences at North Carolina State University and the Department of Bioinformatics at the MDI Biological Laboratory.

CTD was launched on the web on November 12, 2004.

Goals and objectives

One of the primary goals of CTD is to advance the understanding of the effects of environmental chemicals on human health.

The etiology of many chronic diseases involves interactions between environmental factors and genes that modulate important physiological processes. Chemicals are an important component of the environment. Conditions such as asthma, cancer, diabetes, hypertension, immunodeficiency, and Parkinson's disease are known to be influenced by the environment; however, the molecular mechanisms underlying these correlations are not well understood. CTD may help resolve these mechanisms.

Core data

CTD is a unique resource where biocurators[5][6] read the scientific literature and manually curate four types of core data:

  • Chemical-gene interactions
  • Chemical-disease associations
  • Gene-disease associations
  • Chemical-phenotype associations

Data integration

By integrating the above three data sets, CTD automatically constructs putative chemical-gene-phenotype-disease networks to illuminate molecular mechanisms underlying environmentally-influenced diseases.

These inferred relationships are statistically scored and ranked and can be used by scientists and computational biologists to generate and verify testable hypotheses about toxicogenomic mechanisms and how they relate to human health.

Users can search CTD to explore scientific data for chemicals, genes, diseases, or interactions between any of these three concepts. Currently, CTD integrates toxicogenomic data for vertebrates and invertebrates.

CTD integrates data from or hyperlinks to these databases:

CTD Publications

The most up-to-date extensive list of peer-reviewed scientific articles about CTD is available from their Publications page


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External links

  • Comparative Toxicogenomics Database
  • MDI Biological Laboratory
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