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Cyclin-dependent kinase 7

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Title: Cyclin-dependent kinase 7  
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Subject: P53, GTF2H1, Postreplication checkpoint, Cellular apoptosis susceptibility protein, Cyclin B2
Collection: Cell Cycle, Proteins
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Cyclin-dependent kinase 7

Cyclin-dependent kinase 7

PDB rendering based on 1ua2.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; CAK1; CDKN7; HCAK; MO15; STK1; p39MO15
External IDs ChEMBL: GeneCards:
EC number
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Cell division protein kinase 7 is an enzyme that in humans is encoded by the CDK7 gene.[1]

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.[2]


Cyclin-dependent kinase 7 has been shown to interact with XPB,[3][4][5] Cyclin H,[5][6][7] P53,[8][9] Androgen receptor,[10] GTF2H1,[4][5][11] MNAT1[5][12] and SUPT5H.[7]

See also


  1. ^ Fisher RP, Morgan DO (September 1994). "A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase". Cell 78 (4): 713–24.  
  2. ^ "Entrez Gene: CDK7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)". 
  3. ^ Giglia-Mari, Giuseppina; Coin Frederic, Ranish Jeffrey A, Hoogstraten Deborah, Theil Arjan, Wijgers Nils, Jaspers Nicolaas G J, Raams Anja, Argentini Manuela, van der Spek P J, Botta Elena, Stefanini Miria, Egly Jean-Marc, Aebersold Ruedi, Hoeijmakers Jan H J, Vermeulen Wim (July 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. (United States) 36 (7): 714–9.  
  4. ^ a b Rossignol, M; Kolb-Cheynel I; Egly J M (April 1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. (ENGLAND) 16 (7): 1628–37.  
  5. ^ a b c d Yee, A; Nichols M A; Wu L; Hall F L; Kobayashi R; Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. (UNITED STATES) 55 (24): 6058–62.  
  6. ^ Mäkelä, T P; Tassan J P; Nigg E A; Frutiger S; Hughes G J; Weinberg R A (September 1994). "A cyclin associated with the CDK-activating kinase MO15".  
  7. ^ a b Garber, M E; Mayall T P; Suess E M; Meisenhelder J; Thompson N E; Jones K A (September 2000). "CDK9 Autophosphorylation Regulates High-Affinity Binding of the Human Immunodeficiency Virus Type 1 Tat–P-TEFb Complex to TAR RNA". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6958–69.  
  8. ^ Ko, L J; Shieh S Y; Chen X; Jayaraman L; Tamai K; Taya Y; Prives C; Pan Z Q (December 1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner". Mol. Cell. Biol. (UNITED STATES) 17 (12): 7220–9.  
  9. ^ Schneider, E; Montenarh M; Wagner P (November 1998). "Regulation of CAK kinase activity by p53". Oncogene (ENGLAND) 17 (21): 2733–41.  
  10. ^ Lee, D K; Duan H O; Chang C (March 2000). "From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator". J. Biol. Chem. (UNITED STATES) 275 (13): 9308–13.  
  11. ^ Shiekhattar, R; Mermelstein F; Fisher R P; Drapkin R; Dynlacht B; Wessling H C; Morgan D O; Reinberg D (March 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH".  
  12. ^ Talukder, Amjad H; Mishra Sandip K; Mandal Mahitosh; Balasenthil Seetharaman; Mehta Sonal; Sahin Aysegul A; Barnes Christopher J; Kumar Rakesh (March 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". J. Biol. Chem. (United States) 278 (13): 11676–85.  

Further reading

  • Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7.  
  • Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9.  
  • Shiekhattar R, Mermelstein F, Fisher RP, et al. (1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature 374 (6519): 283–7.  
  • Aprelikova O, Xiong Y, Liu ET (1995). "Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase". J. Biol. Chem. 270 (31): 18195–7.  
  • Serizawa H, Mäkelä TP, Conaway JW, et al. (1995). "Association of Cdk-activating kinase subunits with transcription factor TFIIH". Nature 374 (6519): 280–2.  
  • Tassan JP, Schultz SJ, Bartek J, Nigg EA (1994). "Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)". J. Cell Biol. 127 (2): 467–78.  
  • Darbon JM, Devault A, Taviaux S, et al. (1994). "Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase". Oncogene 9 (11): 3127–38.  
  • Williams RT, Wu L, Carbonaro-Hall DA, Hall FL (1994). "Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells". Arch. Biochem. Biophys. 314 (1): 99–106.  
  • Mäkelä TP, Tassan JP, Nigg EA, et al. (1994). "A cyclin associated with the CDK-activating kinase MO15". Nature 371 (6494): 254–7.  
  • Levedakou EN, He M, Baptist EW, et al. (1994). "Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern". Oncogene 9 (7): 1977–88.  
  • Wu L, Yee A, Liu L, et al. (1994). "Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase". Oncogene 9 (7): 2089–96.  
  • Yee A, Nichols MA, Wu L, et al. (1996). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62.  
  • Blau J, Xiao H, McCracken S, et al. (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55.  
  • Bartkova J, Zemanova M, Bartek J (1996). "Expression of CDK7/CAK in normal and tumor cells of diverse histogenesis, cell-cycle position and differentiation". Int. J. Cancer 66 (6): 732–7.  
  • Reardon JT, Ge H, Gibbs E, et al. (1996). "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6482–7.  
  • Drapkin R, Le Roy G, Cho H, et al. (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93.  
  • Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science 274 (5287): 605–10.  
  • Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature 384 (6607): 375–8.  
  • García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8.  

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