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Cyclin B2

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Title: Cyclin B2  
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Subject: Postreplication checkpoint, Cellular apoptosis susceptibility protein, FOXM1, CDKN2D, Start point (yeast)
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Cyclin B2

Cyclin B2
Symbols  ; HsT17299
External IDs ChEMBL: GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene. Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.[1]


  • See also 1
  • Interactions 2
  • References 3
  • Further reading 4

See also


Cyclin B2 has been shown to interact with TGF beta receptor 2.[2]


  1. ^ "Entrez Gene: CCNB2 cyclin B2". 
  2. ^ Liu, J H; Wei S; Burnette P K; Gamero A M; Hutton M; Djeu J Y (Jan 1999). "Functional association of TGF-beta receptor II with cyclin B". Oncogene (ENGLAND) 18 (1): 269–75.  

Further reading

  • He J, Choe S, Walker R, et al. (1995). "Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity.". J. Virol. 69 (11): 6705–11.  
  • Re F, Braaten D, Franke EK, Luban J (1995). "Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B.". J. Virol. 69 (11): 6859–64.  
  • Di Marzio P, Choe S, Ebright M, et al. (1996). "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.". J. Virol. 69 (12): 7909–16.  
  • Jowett JB, Planelles V, Poon B, et al. (1995). "The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle.". J. Virol. 69 (10): 6304–13.  
  • Jackman M, Firth M, Pines J (1995). "Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus.". EMBO J. 14 (8): 1646–54.  
  • Pines J, Hunter T (1994). "The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B.". EMBO J. 13 (16): 3772–81.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4.  
  • Poon B, Jowett JB, Stewart SA, et al. (1997). "Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard.". J. Virol. 71 (5): 3961–71.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56.  
  • Mahalingam S, Ayyavoo V, Patel M, et al. (1998). "HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3419–24.  
  • Brandeis M, Rosewell I, Carrington M, et al. (1998). "Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4344–9.  
  • Felzien LK, Woffendin C, Hottiger MO, et al. (1998). "HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator.". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5281–6.  
  • Liu JH, Wei S, Burnette PK, et al. (1999). "Functional association of TGF-beta receptor II with cyclin B.". Oncogene 18 (1): 269–75.  
  • Elder RT, Yu M, Chen M, et al. (2000). "Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint.". Virus Res. 68 (2): 161–73.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95.  
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35.  
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92.  
  • Elder RT, Yu M, Chen M, et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.". Virology 287 (2): 359–70.  
  • Mouland AJ, Coady M, Yao XJ, Cohen EA (2002). "Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression.". Virology 292 (2): 321–30.  

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