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Cytochrome b5 reductase

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Title: Cytochrome b5 reductase  
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Subject: Hemoglobin
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Cytochrome b5 reductase

cytochrome-b5 reductase
Ribbon diagram of erythrocytic methemoglobin reductase with FAD bound. From ​.
EC number
CAS number 9032-25-1
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Cytochrome-b5 reductase (also known as methemoglobin reductase) is a NADH-dependent enzyme that converts methemoglobin to hemoglobin. It contains FAD and catalyzes the reaction:

NADH + H+ + 2 ferricytochrome b5 = NAD+ + 2 ferrocytochrome b5

The following four human genes encode cytochrome-b5 reductases:

See also

External links

  • Cytochrome-B(5) Reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
  • ​ - crystal structure of rat CBR complexed with NAD
  • ​ - crystal structure of pig liver CBR
  • ​ - crystal structure of human erythrocyte CBR
  • IPR001834 - InterPro entry for CBR
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