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Evoxine

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Evoxine

Evoxine
IUPAC name

(±)-1-(4,8-Dimethoxyfuro[2,3-b]quinolin-7-yl)oxy-3-methylbutane-2,3-diol

Other names

Haploperine

Identifiers
CAS number
PubChem
ChemSpider
ChEMBL
ATC code ATC code none
Jmol-3D images Image 1
Properties
Molecular formula C18H21NO6
Molar mass 347.36 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY   YesY/N?)

Evoxine (haploperine) is a furoquinoline alkaloid with hypnotic and sedative effects. It is found naturally in a variety of Australian and African plants including Evodia xanthoxyloides[1] and Teclea gerrardii.[2]

References

  1. ^ Eastwood, FW; Hughes, GK; Ritchie, E. (1954). "Alkaloids of the Australian Rutaceae: Evodia xanthoxyloides F.Muell. IV. The structures of Evoxine and Evoxoidine". Australian Journal of Chemistry 7 (1): 87–98.  
  2. ^ Waffo, AF; Coombes, PH; Crouch, NR; Mulholland, DA; El Amin, SM; Smith, PJ (2007). "Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa.". Phytochemistry 68 (5): 663–7.  
GABAA
agonists/PAMs
Alcohols:
Barbiturates:
Benzodiazepines:
Carbamates:
Neuroactive Steroids:
Nonbenzodiazepines:
Phenols:
Piperidinediones:
Quinazolinones:
Volatiles/gases
Others:
GABAB
agonists
H1 inverse
agonists
Antihistamines:
Antidepressants
Antipsychotics
α1-Adrenergic
antagonists
Antidepressants
Antipsychotics
Others:
α2-Adrenergic
agonists
5-HT2A
antagonists
Antidepressants
Antipsychotics
Others:
Melatonin
agonists
Orexin
antagonists
Others


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