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Feline sarcoma oncogene

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Title: Feline sarcoma oncogene  
Author: World Heritage Encyclopedia
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Subject: RTK class III, Fyn-related kinase, DDR1, AXL receptor tyrosine kinase, Leukocyte receptor tyrosine kinase
Publisher: World Heritage Encyclopedia

Feline sarcoma oncogene

FES proto-oncogene, tyrosine kinase

PDB rendering based on 1wqu.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; FPS
External IDs ChEMBL: GeneCards:
EC number
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Proto-oncogene tyrosine-protein kinase Fes/Fps is an enzyme that in humans is encoded by the FES gene.[1][2] This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.[2]


Feline sarcoma oncogene has been shown to interact with BCAR1[3] and BCR gene.[4][5]


  1. ^ Bowden DW, Akots G, Rothschild CB (September 1991). "An insertion deletion polymorphism associated with C-FES". Nucleic Acids Res 19 (15): 4311.  
  2. ^ a b "Entrez Gene: FES feline sarcoma oncogene". 
  3. ^ Jücker, M; McKenna K; da Silva A J; Rudd C E; Feldman R A (January 1997). "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling". J. Biol. Chem. (UNITED STATES) 272 (4): 2104–9.  
  4. ^ Lionberger, J M; Smithgall T E (February 2000). "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl". Cancer Res. (UNITED STATES) 60 (4): 1097–103.  
  5. ^ Maru, Y; Peters K L; Afar D E; Shibuya M; Witte O N; Smithgall T E (February 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Mol. Cell. Biol. (UNITED STATES) 15 (2): 835–42.  

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