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Title: Figitumumab  
Author: World Heritage Encyclopedia
Language: English
Subject: List of therapeutic monoclonal antibodies
Publisher: World Heritage Encyclopedia


Figitumumab (previously CP-751871) is a monoclonal antibody[1] targeting the insulin-like growth factor-1 receptor being investigated for the treatment of various types of cancer, for example adrenocortical carcinoma[2] and non-small cell lung cancer (NSCLC).[3]

This drug is being developed by Pfizer.

Anti-cancer mechanism

See Insulin-like growth factor 1 receptor role in cancer.

Clinical trials

The first phase III trial (for NSCLC) was suspended in December 2009 due to excess deaths[4] but others continue.[5][6]

It will be included in the forthcoming I-SPY2 breast cancer trial.[7]


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