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Gianotti–Crosti syndrome

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Title: Gianotti–Crosti syndrome  
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Subject: List of cutaneous conditions, Hepatitis B, Impetigo herpetiformis, Verrucae palmares et plantares, Milker's nodule
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Gianotti–Crosti syndrome

Gianotti–Crosti syndrome
Classification and external resources
ICD-10 L44.4 (ILDS L44.400)
ICD-9 057.8
DiseasesDB 32236
eMedicine derm/165
MeSH D000169

Gianotti–Crosti syndrome (also known as "Infantile papular acrodermatitis,"[1] "Papular acrodermatitis of childhood,"[1] and "Papulovesicular acrolocated syndrome"[2]:389) is a reaction of the skin to a viral infection.[3] Hepatitis B[4] and Epstein-Barr virus are the most frequently reported etiologies. Other incriminated viruses are hepatitis A, hepatitis non A-non B, strep, cytomegalovirus,[5] coxsackie, adenovirus, enterovirus, rotavirus, rubella, HIV and parainfluenza.[6]

It is named for Ferdinando Gianotti and Agostino Crosti.[7][8]

Clinical features

Gianotti–Crosti syndrome mainly affects infants and young children. Children of age as low as 1.5 months and up to 12 years of age are reported to be affected.[9] It is generally recognized as a papular or papulovesicular skin rash occurring mainly on the face and distal aspects of the four limbs. Purpura is generally not seen but may develop following application of tourniquet. However extensive purpura without any hemorrhagic disorder has been reported.[9] The presence of less florid truncal lesions does not exclude the diagnosis. Lymphadenopathy and hepatomegaly are sometimes noted. Raised liver transaminases with no rise in conjugated and unconjugated bilirubin are sometimes detectable, although the absence of such does not exclude the diagnosis. Spontaneous disappearance of the rash usually occurs after 15–60 days.


The diagnosis of Gianotti–Crosti syndrome is clinical. A validated diagnostic criteria[10][11][12] is as follows:

A patient is diagnosed as having Gianotti–Crosti syndrome if:

  1. On at least one occasion or clinical encounter, he/she exhibits all the positive clinical features,
  2. On all occasions or clinical encounters related to the rash, he/she does not exhibit any of the negative clinical features,
  3. None of the differential diagnoses is considered to be more likely than Gianotti–Crosti syndrome on clinical judgment, and
  4. If lesional biopsy is performed, the histopathological findings are consistent with Gianotti–Crosti syndrome.

The positive clinical features are:

  • Monomorphous, flat-topped, pink-brown papules or papulovesicles 1-10mm in diameter.
  • At least three of the following four sites involved – (1) cheeks, (2) buttocks, (3) extensor surfaces of forearms, and (4) extensor surfaces of legs.
  • Being symmetrical, and
  • Lasting for at least ten days.

The negative clinical features are:

  • Extensive truncal lesions, and
  • Scaly lesions.

Differential diagnosis

The differential diagnoses are: acrodermatitis enteropathica, erythema infectiosum, erythema multiforme, hand-foot-and-mouth disease, Henoch-Schönlein purpura, Kawasaki disease, lichen planus, papular urticaria, papular purpuric gloves and socks syndrome, and scabies.


Gianotti-Crosti disease is a harmless and self-limiting condition, so no treatment may be required.[13] Treatment is mainly focused on controlling itching, symptomatic relief and to avoid any further complications. For symptomatic relief from itching, oral antihistamines or any soothing lotions like calamine lotion or zinc oxide may be used. If there are any associated conditions like streptococcal infections, antibiotics may be required.[10][11][12][13]

See also


  1. ^ a b Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1228.  
  2. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier.  
  3. ^ "Gianotti-crosti syndrome, papulovesicular acrodermatitis. DermNet NZ". 
  4. ^ Michitaka K, Horiike N, Chen Y, et al. (August 2004). "Gianotti-Crosti syndrome caused by acute hepatitis B virus genotype D infection". Internal Medicine (Tokyo, Japan) 43 (8): 696–9.  
  5. ^ Haki M, Tsuchida M, Kotsuji M, et al. (October 1997). "Gianotti-Crosti syndrome associated with cytomegalovirus antigenemia after bone marrow transplantation". Bone Marrow Transplantation 20 (8): 691–3.  
  6. ^ Chandrasekaran M, Mukherjee S (September 2007). "Gianotti Crosti syndrome". Indian Pediatrics 44 (9): 695.  
  7. ^ synd/4051 at Who Named It?
  8. ^ CROSTI A, GIANOTTI F (November 1957). "[Eruptive dermatosis of probable viral origin situated on the acra.]". Dermatologica (in French) 115 (5): 671–7.  
  9. ^ a b Sarma, N; Sarkar UK (Jan–Mar 2013). "Hemorrhagic Gianotti-Crosti Syndrome in a One and Half Month old Infant: An Extremely Unusual Presentation". Ind J Dermatol 58 (1): 65–67.  
  10. ^ a b Chuh, AA (September 2001). "Diagnostic criteria for Gianotti-Crosti syndrome: a prospective case-control study for validity assessment.". Cutis; cutaneous medicine for the practitioner 68 (3): 207–13.  
  11. ^ a b Chuh, Antonio; Lee, Albert; Zawar, Vijay (1 September 2004). "The Diagnostic Criteria of Gianotti-Crosti Syndrome: Are They Applicable to Children in India?". Pediatric Dermatology 21 (5): 542–547.  
  12. ^ a b Chuh, Antonio; Zawar, Vijay; Law, Michelle; Sciallis, Gabriel (2 January 2012). "Gianotti-Crosti syndrome, pityriasis rosea, asymmetrical periflexural exanthem, unilateral mediothoracic exanthem, eruptive pseudoangiomatosis and papular-purpuric gloves and socks syndrome: a brief review and arguments for diagnostic criteria". Infectious Disease Reports 4 (1).  
  13. ^ a b "Gianotti-crosti syndrome. Dermatalk". 
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