Jte 7-31

JTE 7-31

IUPAC name 2-[2-(4-hydroxyphenyl)ethyl]-5-methoxy-4-(pentylamino)-2,3-dihydro-1H-isoindol-1-one
Identifiers
CAS number	^N
PubChem
ChemSpider	^Y
Jmol-3D images	Image 1
SMILES Oc1ccc(cc1)CCN3Cc2c(ccc(OC)c2NCCCCC)C3=O
InChI InChI=1S/C22H28N2O3/c1-3-4-5-13-23-21-19-15-24(14-12-16-6-8-17(25)9-7-16)22(26)18(19)10-11-20(21)27-2/h6-11,23,25H,3-5,12-15H2,1-2H3^Y Key: FMUMUYFMLZGXJR-UHFFFAOYSA-N^Y InChI=1/C22H28N2O3/c1-3-4-5-13-23-21-19-15-24(14-12-16-6-8-17(25)9-7-16)22(26)18(19)10-11-20(21)27-2/h6-11,23,25H,3-5,12-15H2,1-2H3 Key: FMUMUYFMLZGXJR-UHFFFAOYAA
Properties
Molecular formula	C₂₂H₂₈N₂O₃
Molar mass	368.469
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N Y/N?)

JTE 7-31 is a selective cannabinoid receptor agonist invented by Japan Tobacco.^[1]^[2] It is a reasonably highly selective CB₂ agonist, but still retains appreciable affinity at CB₁, with a K_i of 0.088nM at CB₂ vs 11nM at CB₁.

References

^ WO patent 1997/029079, Inaba T, Kaya T, Iwamura H, "Novel compounds and pharmaceutical use thereof", granted 1997-14-08
^ US patent 6017919, Inaba T, Kaya T, Iwamura H, "Compounds and pharmaceutical use thereof", granted 2000-01-25

Cannabinoids

Phytocannabinoids

Cannabinoid
metabolites

Endogenous
cannabinoids

Arachidonoyl ethanolamide (Anandamide or AEA)
2-Arachidonoylglycerol (2-AG)
2-Arachidonyl glyceryl ether (noladin ether)
N-Arachidonoyl dopamine (NADA)
Oleamide
RVD-Hpα
Virodhamine

Synthetic
cannabinoid
receptor
agonists

Classical cannabinoids (Dibenzopyrans)	A-40174 A-41988 A-42574 Ajulemic acid AM-087 AM-411 AM-855 AM-905 AM-906 AM-919 AM-926 AM-938 AM-2389 AM-4030 AMG-1 AMG-3 AMG-36 AMG-41 Dexanabinol (HU-211) DMHP Dronabinol HHC HU-210 HU-243 JWH-051 JWH-133 JWH-139 JWH-161 JWH-229 JWH-359 KM-233 L-759,633 L-759,656 Levonantradol (CP 50,5561) Menabitan Nabazenil Nabidrox (Canbisol) Nabilone Nabitan Naboctate O-224 O-581 O-774 O-806 O-823 O-1057 O-1125 O-1191 O-1238 O-2048 O-2113 O-2365 O-2372 O-2373 O-2383 O-2426 O-2484 O-2545 O-2694 O-2715 O-2716 O-3223 O-3226 Parahexyl Pirnabine THC-O-acetate THC-O-phosphate

Nonclassical cannabinoids	Cannabicyclohexanol CP 47,497 (C6)-CP 47,497 (C9)-CP 47,497 CP 55,244 CP 55,940 HU-308 HU-320 HU-331 HU-336 HU-345 HU-910 Nonabine O-1376 O-1422 O-1601 O-1656 O-1657 O-1660 O-1871 SPA-229 Tinabinol 2-Isopropyl-5-methyl-1- (2,6-dihydroxy-4-nonylphenyl)cyclohex-1-ene

Benzoylindoles	1-Butyl-3-(2-methoxybenzoyl)indole 1-Butyl-3-(4-methoxybenzoyl)indole 1-Pentyl-3-(2-methoxybenzoyl)indole AM-630 AM-679 AM-694 AM-1241 AM-2233 GW-405,833 (L-768,242) Pravadoline RCS-4 WIN 54,461

Naphthoylindoles	AM-1220 AM-1221 AM-1235 AM-2201 AM-2232 EAM-2201 JWH-007 JWH-015 JWH-018 JWH-019 JWH-073 JWH-081 JWH-098 JWH-116 JWH-122 JWH-149 JWH-164 JWH-182 JWH-193 JWH-198 JWH-200 JWH-210 JWH-398 JWH-424 MAM-2201

Naphthoylindazoles	THJ-018 THJ-2201

Pyrrolobenzoxazines	WIN 55,212-2

Naphthylmethylindoles	JWH-175 JWH-176 JWH-184 JWH-185 JWH-192 JWH-194 JWH-195 JWH-196 JWH-197 JWH-199

Phenylacetylindoles	Cannabipiperidiethanone JWH-167 JWH-203 JWH-249 JWH-250 JWH-251 JWH-302 RCS-8

Indole-3-carboxamides	ADBICA Org 28312 Org 28611 SDB-001 (2NE1) SDB-006 STS-135 UR-12 (MN-25)

Indole-3-carboxylates	5F-PB-22 QUCHIC (BB-22) QUPIC (PB-22)

Indazole-3-carboxamides	AB-CHMINACA AB-FUBINACA AB-PINACA ADB-FUBINACA APINACA (AKB48)

Naphthoylpyrroles	JWH-030 JWH-147 JWH-307 JWH-369 JWH-370

Eicosanoids	AM-883 AM-1346 ACEA ACPA Methanandamide (AM-356) O-585 O-689 O-1812 O-1860 O-1861

Others	4-HTMPIPO 5-Fluoropentyl-3-pyridinoylindole A-796,260 A-834,735 A-836,339 A-955,840 Abnormal cannabidiol AB-001 AM-1248 AM-1714 AZ-11713908 BAY 38-7271 BAY 59-3074 CB-13 CB-86 CBS-0550 GW-842,166X JTE 7-31 LASSBio-881 LBP-1 Leelamine MDA-7 MDA-19 NESS-040C5 NMP-7 O-889 O-1269 O-1270 O-1399 O-1602 O-2220 PF-03550096 PSB-SB-1202 S-444,823 SER-601 Tedalinab UR-144 URB-447 VSN-16 WIN 56,098 XLR-11

Allosteric
modulators of
cannabinoid
receptors

Endocannabinoid
activity enhancers

Cannabinoid
receptor
antagonists and
inverse agonists

Categories

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Jte 7-31

Jte 7-31

See also

References

Categories

PubChem

Encyclopedia Article

ChemSpider

Encyclopedia Article

Chemical formula

Encyclopedia Article

Japan Tobacco

Encyclopedia Article

Suggestions

Win 55,212-2

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Jwh-018

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N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide

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Ur-144

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Cannabipiperidiethanone

Encyclopedia Article