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Jose F. Caro

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Jose F. Caro

Jose F. Caro

José F. Caro, M.D. (born Granada, Spain, 1948) is an American physician, scientist, and educator most notable for his research in obesity and diabetes. The Institute for Scientific Information listed him the third most cited investigator in the world in the field of obesity research during the 1991-2000 period for his work on Leptin.[1][2][3][4][5] Caro is also an artist.


Caro received his M.D. degree in 1973 from the Complutense University of Madrid, Spain and University of the Republic, Uruguay.[6] He completed his residency training in Internal medicine at Jefferson Medical College of Thomas Jefferson University in 1977. Caro completed his fellowship training in Endocrinology and Metabolism in 1981 at the Strong Memorial Hospital, University of Rochester School of Medicine and Dentistry, becoming certified in Endocrinology and Metabolism by the American Board of Internal Medicine. These formative years were funded by training grants from the American Diabetes Association and the Juvenile Diabetes Research Foundation, which also sustained his involvement in diabetes research. His early research output paved the way for him to become an independent investigator soon thereafter by receiving in 1981 the Wayne Newton Research Award from the American Diabetes Association and in 1982 the New Investigator Research Award from the National Institutes of Health.[7][8][9]

Medical career

Caro was the founding Director of the Division of Endocrinology and Metabolism of The Brody School of Medicine at East Carolina University (ECU) (1982-1991). He established the ECU Diabetes Center, funded by the ECU Diabetes Program Project Grant[10] from the National Institutes of Health, a multidisciplinary collaborative endeavor by scientists with specialties in medicine, biochemistry, and surgery. Among their contribution to the understanding of Insulin resistance in Type 2 Diabetes stands out the discovery of alterations in the insulin receptor kinase in the human liver.[11] Also, in collaboration with Walter Pories, that gastric bypass surgery induced a long lasting remission of the disease in about 80% of obese people with diabetes.[12] Moreover, in people with pre-diabetes the gastric bypass surgery prevents the development of diabetes by about 40 fold.[13] At the time of such work the gastric bypass surgery was an experimental procedure, which is now well accepted in standard clinical practice. For the sum of this work Caro was elected a member of The American Society for Clinical Investigation (Young Turk).[14]

In 1991 Caro was recruited by his US alma mater , Jefferson Medical College of Thomas Jefferson University, to become the Magee Professor of Medicine and the 16th Chairman of the Department.[15] Subsecuently he was elected to the Association of American Physicians (Old Turk),[10] and appointed by the Secretary of Health and Human Services to the Advisory Council of the National Institutes of Health (2000-2004).[16] His research on leptin published in the Journal of Clinical Investigation in 1995[10] was the first to explore leptin following the discovery of the hormone by Friedman’s laboratory in 1994.[17] Caro’s laboratory demonstrated that human obesity is not characterized by leptin deficiency but by leptin resistance and helped usher in "leptinomania" in the study of obesity.[4]

In 1996 Caro was named Vice President of Endocrine Research and Clinical Investigation at Eli Lilly & comp.[18] After a decade of work in drug discovery Caro was recruited again by the Brody School of Medicine at ECU, where he became the Associate Dean for Clinical Investigation[19] and the founding Director of the ECU Metabolic Institute.[20][21] Caro left Medicine in 2008 as the Distinguished Professor of Medicine Emeritus[22] to start a new career in art.

Art career

Maternity, pastel by Jose F. Caro

Caro went back to school to study fine arts at the Indianapolis Art Center, and the Carteret Community College.[23] Alongside with this non-degree formal education, for several years Caro has been painting with colleagues while attending art classes and workshops. After submission of his portfolio he was jury-elected an Associate Member of the Pastel Society of America in 2013.[24] Since then Caro’s pastel paintings have been juried at various US and international exhibits. One notable piece of his pastel paintings is I am not a little girl anymore presented at the 23rd International Association of Pastel Societies Juried Exhibition,[25] and awarded the 3rd place in the Artist’s Magazine January 2014 contest.[26] The painting is said to "capture the sense of isolation and alienation that so often accompany a girl’s journey into adolescence.[10] Another significant piece of Caro´s is the pastel Maternity, juried at the 10th Annual Northeast National Pastel Exhibition and receiving the "Outstanding Portrait Award". According to jurors this painting represents "a metaphor of modern family, the interplay between the oldest of bonds between a mother and daughter and the new technology, the tension between physical connection and mental distance; each of the two is in her own universe on her owm device yet both warmly bonded together".[10][27] Caro´s inspiration for his realistic and psychological paintings are mainly his family and the sea. The artist recently received an Award of Merit from the Degas Pastel Society.[28]


  1. ^ Essential Science Indicators: Special Topics. Obesity. Accessed Dec. 5, 2013
  2. ^ Considine RV, Considine EL, Williams CJ, Nyce MR, Magosin SA, Bauer TL, Rosato EL, Colberg J and Caro JF."Evidence against either a premature codon or the absence of obese gene mRNA in human obesity." The Journal of Clinical Investigation 95:2986-2988, 1995.
  3. ^ Fitzgerald, Susan. "Doubt Is Cast On Role of Faulty Obese Gene. The Cause Of Obesity In Mice Does Not Apply To Humans, Researchers Said. If Only It Did, They Added." The Inquirer. June 1, 1995
  4. ^ a b Caro, Jose, edited by Thomas W. Durso. "Genetics." The Scientist. June 23, 1997
  5. ^ Flam, Faye. "Hunger Suppressor Slimmed Lab Mice, But Not Humans. Obese Mice Have A Shortage Of The Hormone Leptin. Heavy People Have A Surplus. More Leptin Won’t Help" The Inquirer. Feb. 1, 1996
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