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Title: Kaempferol  
Author: World Heritage Encyclopedia
Language: English
Subject: Flavonols, Kaempferol 7-O-glucoside, Rhamnetin, Pinobanksin, Miquelianin
Collection: Antidepressants, Kaempferol, Xanthine Oxidase Inhibitors
Publisher: World Heritage Encyclopedia


CAS number  YesY
ChemSpider  N
Jmol-3D images Image 1
Molecular formula C15H10O6
Molar mass 286.23 g/mol
Density 1.688 g/mL
Melting point 276 to 278 °C (529 to 532 °F; 549 to 551 K)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N   YesY/N?)

Kaempferol (/'kiːmpfərɒl/) is a natural flavonol, a type of flavonoid, that has been isolated from tea, broccoli, Delphinium, Witch-hazel, grapefruit, cabbage, kale, beans, endive, leek, tomato, strawberries, grapes, brussels sprouts, apples and other plant sources. Kaempferol is a yellow crystalline solid with a melting point of 276-278 °C. It is slightly soluble in water but soluble in hot ethanol and diethyl ether.


  • Natural occurrences 1
    • List of the plants that contains the chemical 1.1
      • In plants used in traditional medicine 1.1.1
    • In food 1.2
  • Biological activity 2
  • Metabolism 3
    • Glycosides 3.1
  • References 4
  • External links 5

Natural occurrences

Kaempferol is also present in Kaempferia galanga[1] and Opuntia ficus-indica var. saboten.[2]

Kaempferol and its glucoside can be isolated from the methanolic extract of fronds of the fern Phegopteris connectilis.[3]

List of the plants that contains the chemical

It can be found in Delphinium.

In plants used in traditional medicine

Kaempferol has been identified in many plant species commonly used in traditional medicine. It has been found in Acacia nilotica, Adansonia digitata, Albizia lebbeck, Aloe vera, Amburana cearensis, Ammi majus, Angelica keiskei, Ardisia japonica, Bauhinia forficata, Bauhinia microstachya, Bunium persicum, Capparis spinosa, Cassia alata, Centella asiatica, Chromolaena odorata, Cissus sicyoides, Coccinia grandis, Crassocephalum crepidioides, Crocus sativus, Cynanchum acutum, Cynanchum chinense, Dicliptera chinensis, Equisetum arvense, Euphorbia pekinensis, Ficaria verna, Foeniculum vulgare, Galega officinalis, Ginkgo biloba, Glycine max, Grindelia robusta, Gymnema sylvestre, Helleborus niger, Hippophae rhamnoides, Houttuynia cordata, Hypericum perforatum, Impatiens balsamina, Lamium album, Laurus nobilis, Lonicera japonica, Lycium barbarum, Lycium chinense, Lysimachia vulgaris, Malva parviflora, Peumus boldus, Phyllanthus emblica, Ribes nigrum, Rosmarinus officinalis, Sambucus nigra, Sanguisorba minor, Siraitia grosvenori, Solanum nigrum, Solenostemma argel, Solidago virgaaurea, Sutherlandia frutescens, Symphytum officinale, Syzygium aromaticum, Tilia americana, Toona sinensis, Trigonella foenum-graecum, Tropaeolum majus, Vaccinium vitis-idaea, Warburgia ugandensis and Wedelia trilobata.[4]

In food

It can be isolated from tea,[5] capers(135 mg/100g),[6] kale(26 mg/100g),[7] dill(13 mg/100g),[8] broccoli(6 mg/100g),[9] witch-hazel, grapefruit, cabbage, beans, endive, leek, tomato, strawberries, grapes, Brussels sprouts, apples, and other plant sources.

Kaempferol has been identified in many edible plants. It has been found in Allium ampeloprasum (leek), A. cepa (onion), A. schoenoprasum (chives), Amaranthus lividus (amaranth), Angelica keiskei (ashitaba), Armoracia rusticana (horseradish), Artemisia dracunculus (tarragon), Atriplex hortensis (orach), Brassica campestris (Chinese cabbage), B. juncea (mustard), B. napobrassica (rutabagas), B. oleracea (broccoli, Brussels sprouts, green cabbage and kale), B. rapa (turnip greens), Bunias orientalis (Turkish rocket), Camellia sinensis (tea), Capparis spinosa (capers), Celosia argentea (feather cockscomb), Cichorium endivia (endive), Citrus paradisi (grapefruit), Cnidoscolus aconitifolius and C. chayamansa (tree spinach), Coccinia grandis (ivy gourd), Cucumis sativus (cucumber), Cucurbita maxima (squash), Cyamopsis tetragonoloba (cluster bean), Diplotaxis erucoides (wall rocket), Diplotaxis tenuifolia (wild rocket), Eruca sativa (rocket-salad), Foeniculum vulgare (fennel), Fragaria vesca (strawberry), Houttuynia cordata (fishwort), Ipomoea batatas (sweet potato), Lactuca sativa (lettuce), Lepidium sativum (cress), Levisticum officinale (lovage), Lycium barbarum and L. chinense (goji berries), Malus domestica (apple), Momordica cochinchinensis (gac), Morinda citrifolia (Indian mulberry), Nasturtium officinale (watercress), Nepenthes gracilis,[10] Olea europaea (olive oil), Petroselinum crispum (parsley), Phaseolus vulgaris (green beans), Pistacia vera (pistachio), Prunus persica (peach), Raphanus sativus (radishes), Ribes uva-crispa (gooseberries), Rubís fruticosus (blackberries), Rubus idaeus (raspberry), Sambucus nigra (elderberry), Sauropus androgynus (star gooseberry), Sesbania grandiflora (sesbania), Solanum lycopersicum (tomatoes), S. nigrum (nightshade), S. tuberosum (potatoes), Spinacia oleracea (spinach), Vaccinium erythrocarpum, V. acrocarpon, V. microcarpum and V. oxycoccos (cranberries), Vaccinium vitis-idaea (cowberries), Vicia faba (broadbeans), Vigna unguiculata (cowpea), Vitis rotundifolia (muscadine grapes), and Vitis vinífera (grapes).[4] and chia seed.

Biological activity

Some epidemiological studies have found a positive association between the consumption of foods containing kaempferol and a reduced risk of developing several disorders such as cancer and cardiovascular diseases. Numerous preclinical studies have shown kaempferol and some glycosides of kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, antiosteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic, and antiallergic activities (see review article).[4]

Many glycosides of kaempferol, such as kaempferitrin and astragalin, have been isolated as natural products from plants. Kaempferol consumption in tea and broccoli has been associated with reduced risk of heart disease.[11] A related compound, naringenin, may be present at the same time, such as in grapefruit.

Kaempferol gives the flowers of Acacia decurrens and Acacia longifolia their color.[12] Antidepressant properties have been reported in tests on animals.[13],[14][15]

An eight-year study found the consumption of three flavonols (kaempferol, quercetin, and myricetin) correlated with a lower risk of pancreatic cancer among current smokers, but not nonsmokers and exsmokers.[16]

Kaempferol consumption is also correlated with a reduced lung cancer incidence.[17]

Kaempferol may be a potent prophylactic against NOX-mediated neurodegeneration.[18]

Kaempferol has been found to inhibit the enzyme fatty acid amide hydrolase (FAAH).[19] It was also demonstrated to act as agonist of PPARgamma, nuclear receptor that is current pharmacological target for the treatment of diabetes type 2.[20]

A recent study showed that dietary kaempferol alleviates lung fibrosis in mouse experimental model.[21]


The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl methionine and kaempferol to produce S-adenosylhomocysteine and kaempferide.



  1. ^ Mustafa RA. Abdul Hamid A. Mohamed S. Bakar FA. "Total phenolic compounds, flavonoids, and radical scavenging activity of 21 selected tropical plants". Journal of Food Science. 75(1):C28-35, 2010 Jan-Feb.
  2. ^ Ncibi, S; Ben Othman, M; Akacha, A; Krifi, MN; Zourgui, L (2008). "Opuntia ficus indica extract protects against chlorpyrifos-induced damage on mice liver".  
  3. ^ Klaus-Peter, Adam (1999). "Phenolic constituents of the fernPhegopteris connectilis". Phytochemistry 52 (5): 929–934.  
  4. ^ a b c Calderon-Montaño JM, Burgos-Moron E, Perez-Guerrero C, Lopez-Lazaro M. (2011). "A review on the dietary flavonoid kaempferol.". Mini Rev Med Chem. 11 (4): 298–344.  
  5. ^ Jun Seong Park, Ho Sik Rho, Duck Hee Kim, and Ih Seop Chang (2006). "Enzymatic Preparation of Kaempferol from Green Tea Seed and Its Antioxidant Activity".  
  6. ^ "Capers, canned". 
  7. ^ "Kale, raw". 
  8. ^ "Dill weed, fresh". 
  9. ^ "Broccoli, raw". 
  10. ^ "Phenolic constituents from the leaves of the carnivorous plant Nepenthes gracilis". Phenolic constituents from the leaves of the carnivorous plant Nepenthes gracilis. Fitoterapia. Retrieved 27 February 2012. 
  11. ^ Calderón-Montaño JM, Burgos-Morón E, Pérez-Guerrero C, López-Lázaro M."A review on the dietary flavonoid kaempferol. Mini Rev Med Chem. 2011 Apr;11(4):298-344
  12. ^ Lycaeum -- Phytochemistry Intro
  13. ^ Hosseinzadeh, Hossein; Motamedshariaty, Vahidehsadat; Farzin Hadizadeh, Farzin (2007). ) petal, in mice and rats"crocus sativus"Antidepressant effect of Kaempferol, a constituent of saffron ( (PDF). Pharmacologyonline 2: 367–370. Retrieved 2011-06-17. 
  14. ^ Hou Y. Aboukhatwa MA. Lei DL. Manaye K. Khan I. Luo Y."Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice." Neuropharmacology. 58(6):911-20, 2010 May.
  15. ^ Hou, Y; Aboukhatwa, MA; Lei, DL; Manaye, K; Khan, I; Luo, Y (2010). "Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice". Neuropharmacology 58 (6): 911–20.  
  16. ^ Nöthlings Ute, Murphy Suzanne P., Wilkens Lynne R., Henderson Brian E., Kolone Laurence N. (2007). "Flavonols and Pancreatic Cancer Risk". American Journal of Epidemiology 166 (8): 924–931.  
  17. ^ Irwin, Kim (May 29, 2008). "Fruits, vegetables, teas may protect smokers from lung cancer". News Releases.  
  18. ^ Jang YJ. Kim J. Shim J. Kim J. Byun S. Oak MH. Lee KW. Lee HJ.,"Kaempferol attenuates 4-hydroxynonenal-induced apoptosis in PC12 cells by directly inhibiting NADPH oxidase". Journal of Pharmacology & Experimental Therapeutics. 337(3):747-54, 2011 Jun.
  19. ^ Thors, L; M Belghiti; CJ Fowler (2008). "Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids". British Journal of Pharmacology. 2 155 (2): 244–252.  
  20. ^ Wang, L; Waltenberger, B; Pferschy-Wenzig, E. M.; Blunder, M; Liu, X; Malainer, C; Blazevic, T; Schwaiger, S; Rollinger, J. M.; Heiss, E. H.; Schuster, D; Kopp, B; Bauer, R; Stuppner, H; Dirsch, V. M.; Atanasov, A. G. (2014). "Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): A review". Biochemical pharmacology.  
  21. ^ Gong JH (Mar 2014). "Inhibition of airway epithelial-to-mesenchymal transition and fibrosis by kaempferol in endotoxin-induced epithelial cells and ovalbumin-sensitized mice.". Lab Invest. 94 (3): 297–308.  
  22. ^ Flavonoids and a proanthrocyanidin from rhizomes of Selliguea feei. Baek Nam-In, Kennelly E.J., Kardono L.B.S., Tsauri S., Padmawinata K., Soejarto D.D. and Kinghorn A.D., Phytochemistry, 1994, vol. 36, no2, pages 513-518, INIST:3300075

External links

  • Flavonoid composition of tea: Comparison of black and green teas
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