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Title: Masoprocol  
Author: World Heritage Encyclopedia
Language: English
Subject: List of drugs: M-Md, Chemotherapy, Cell-cycle nonspecific antineoplastic agents, Hazardous drugs, Thiopurine
Collection: Antineoplastic Drugs, Catechols
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Trade names Actinex
  • US: B (No risk in non-human studies)
Routes of
Pharmacokinetic data
Bioavailability Very low
CAS Registry Number  Y
ATC code L01
PubChem CID:
DrugBank  Y
ChemSpider  Y
Chemical data
Formula C18H22O4
Molecular mass 302.365 g/mol

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.

Also called nordihydroguaiaretic acid, NDGA, and actinex.


Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.[1]


  1. ^ "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". Am. J. Physiol. Endocrinol. Metab. 279 (3): E593–600. September 2000.  

External links

  • MedlinePlus Drug Information
  • Actinex entry in the public domain NCI Cancer Dictionary

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