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Medroxyprogesterone

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Title: Medroxyprogesterone  
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Subject: Progestin, Medroxyprogesterone acetate, Progestogens, Norgesterone, Hydroxyprogesterone heptanoate
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Medroxyprogesterone

Medroxyprogesterone
Systematic (IUPAC) name
(6α)-17-hydroxy-6-methylpregn-4-ene-3,20-dione
Clinical data
Pregnancy
category
  • X
Identifiers
CAS Registry Number
ATC code None
PubChem CID:
ChemSpider
Chemical data
Formula C22H32O3
Molecular mass 344.488 g/mol

Medroxyprogesterone (INN, BAN), also known as 17α-hydroxy-6α-methylprogesterone, and abbreviated as MP, is a steroidal progestin drug which was never marketed for use in humans.[1] An acylated derivative, medroxyprogesterone acetate (MPA), is clinically used as a pharmaceutical medicine.[2] Compared to MPA, MP is over two orders of magnitude less potent as a progestogen.[3] As such, MP itself is not used clinically, though it has seen limited use in veterinary medicine under the trade name Controlestril in France.[4] In addition, it is a metabolite of MPA.[5]

While medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate,[2] what is normally being administered is MPA and not MP.[6]

See also

References

  1. ^ F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1079.  
  2. ^ a b "MedroxyPROGESTERone: Drug Information Provided by Lexi-Comp".  
  3. ^ Pullen MA, Laping N, Edwards R, Bray J (September 2006). "Determination of conformational changes in the progesterone receptor using ELISA-like assays". Steroids 71 (9): 792–8.  
  4. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 638.  
  5. ^ Ishihara M, Kirdani Y, Osawa Y, Sandberg AA (January 1976). "The metabolic fate of medroxyprogesterone acetate in the baboon". J. Steroid Biochem. 7 (1): 65–70.  
  6. ^ Lenco W, Mcknight M, Macdonald AS (January 1975). "Effects of cortisone acetate, methylprednisolone and medroxyprogesterone on wound contracture and epithelization in rabbits". Ann. Surg. 181 (1): 67–73.  



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