World Library  
Flag as Inappropriate
Email this Article

Molecular binding

Article Id: WHEBN0011489016
Reproduction Date:

Title: Molecular binding  
Author: World Heritage Encyclopedia
Language: English
Subject: Binding, Cooperative binding, Zinc finger, Fructose 1,6-bisphosphatase, Alpha-2-Macroglobulin, Enterotoxin, GroES, Birnaviridae, Laminin, Bacterial adhesin
Publisher: World Heritage Encyclopedia

Molecular binding

Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are close to each other. The result of molecular binding is the formation of a molecular complex. A molecular complex in turn is a loose association involving two or more molecules. The attractive bonding between the components of a complex is normally weaker than in a covalent bond.[1]


Molecular binding can be classified into the following types:[2]

  • non-covalent – no chemical bonds are formed between the two interacting molecules hence the association is fully reversible
  • reversible covalent – a chemical bond is formed, however the free energy difference separating the noncovalently-bonded reactants from bonded product is near equilibrium and the activation barrier is relatively low such that the reverse reaction which cleaves the chemical bond easily occurs
  • irreversible covalent – a chemical bond is formed in which the product is thermodynamically much more stable than the reactants such that the reverse reaction does not take place.

Driving force

In order for the complex to be stable, the free energy of complex by definition must be lower than the solvent separated molecules. The binding may be primarily entropy-driven (release of ordered solvent molecules around the isolated molecule that results in a net increase of entropy of the system). When the solvent is water, this known as the hydrophobic effect. Alternatively the binding may be enthalpy-driven where non-covalent attractive forces such as electrostatic attraction, hydrogen bonding, and van der Waals / London dispersion forces are primarily responsible for the formation of a stable complex.[3] Complexes that have a strong entropy contribution to formation tend to have weak enthalpy contributions. Conversely complexes that have strong enthalpy component tend to have a weak entropy component. This phenomenon is known as enthalpy-entropy compensation.[4]


The association constant (KI) also known as the binding constant (KA) between the components of complex is the ratio of the concentration of the complex divided by the product of the concentrations of the isolated components at equilibrium:

A+B \rightleftharpoons AB:\log K_{I} =\log \left(\frac \right)=pK_I


Molecules that can participate in molecular binding include proteins, nucleic acids, carbohydrates, lipids, and small organic molecules such as drugs. Hence the types of complexes that form as a result of molecular binding include:

Proteins that form stable complexes with other molecules are often referred to as receptors while their binding partners are called ligands.[8]

See also


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.