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Myocyte-specific enhancer factor 2A

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Title: Myocyte-specific enhancer factor 2A  
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Subject: Mef2, MEF2D, Thyroid hormone receptor alpha, ASCL1, HDAC9
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Myocyte-specific enhancer factor 2A

Myocyte enhancer factor 2A

PDB rendering based on 1c7u.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; ADCAD1; RSRFC4; RSRFC9; mef2
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene.[1][2] MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26. Certain mutations in MEF2A cause an autosomal dominant form of coronary artery disease and myocardial infarction. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are 1 class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIM][2]

Interactions

Myocyte-specific enhancer factor 2A has been shown to interact with HDAC9,[3][4] MEF2D,[5] MAPK14,[6][7] Histone deacetylase 5,[4] EP300,[8] ASCL1,[9] HDAC4,[3][4] Thyroid hormone receptor alpha[8] and Mothers against decapentaplegic homolog 2.[10]

References

  1. ^ Yu YT, Breitbart RE, Smoot LB, Lee Y, Mahdavi V, Nadal-Ginard B (October 1992). "Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors". Genes Dev 6 (9): 1783–98.  
  2. ^ a b "Entrez Gene: MEF2A MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)". 
  3. ^ a b Miska, E A; Karlsson C; Langley E; Nielsen S J; Pines J; Kouzarides T (September 1999). "HDAC4 deacetylase associates with and represses the MEF2 transcription factor". EMBO J. (ENGLAND) 18 (18): 5099–107.  
  4. ^ a b c Lemercier, C; Verdel A; Galloo B; Curtet S; Brocard M P; Khochbin S (May 2000). "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity". J. Biol. Chem. (UNITED STATES) 275 (20): 15594–9.  
  5. ^ Ornatsky, O I; McDermott J C (October 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". J. Biol. Chem. (UNITED STATES) 271 (40): 24927–33.  
  6. ^ Zhao, M; New L; Kravchenko V V; Kato Y; Gram H; di Padova F; Olson E N; Ulevitch R J; Han J (January 1999). "Regulation of the MEF2 Family of Transcription Factors by p38". Mol. Cell. Biol. (UNITED STATES) 19 (1): 21–30.  
  7. ^ Yang, S H; Galanis A; Sharrocks A D (June 1999). "Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors". Mol. Cell. Biol. (UNITED STATES) 19 (6): 4028–38.  
  8. ^ a b De Luca, Antonio; Severino Anna; De Paolis Paola; Cottone Giuliano; De Luca Luca; De Falco Maria; Porcellini Antonio; Volpe Massimo; Condorelli Gianluigi (February 2003). "p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor". Biochem. J. (England) 369 (Pt 3): 477–84.  
  9. ^ Mao, Z; Nadal-Ginard B (June 1996). "Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A". J. Biol. Chem. (UNITED STATES) 271 (24): 14371–5.  
  10. ^ Quinn, Z A; Yang C C; Wrana J L; McDermott J C (February 2001). "Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins". Nucleic Acids Res. (England) 29 (3): 732–42.  

Further reading

External links


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