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Naloxol

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Title: Naloxol  
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Subject: Naloxone, List of opioids, Hydrocodone, Kobret, 6β-Naltrexol-d4
Collection: Human Drug Metabolites, Metabolism, Morphinans, Opioid Antagonists
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Naloxol

Naloxol
α-Naloxol
α-Naloxol
β-Naloxol
β-Naloxol
Identifiers
CAS number  (α) YesY,  (β) YesY,  (α/β) YesY
PubChem  (α),  (β)
ChemSpider  (α) N,  (β)
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C19H23NO4
Molar mass 329.39 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N   YesY/N?)

Naloxol is an opioid antagonist closely related to naloxone. It exists in two isomeric forms, α-naloxol and β-naloxol.

α-Naloxol is a human reduction of the ketone group, and β-naloxol can be prepared from α-naloxol by a Mitsunobu reaction.[2]

See also

References

  1. ^ Weinstein, S. H.; Pfeffer, M.; Schor, J. M.; Indindoli, L.; Mintz, M. (1971). "Metabolites of naloxone in human urine". Journal of Pharmaceutical Sciences 60 (10): 1567–1568.  
  2. ^ Simon, C (1994). "Stereoselective synthesis of β-naltrexol, β-naloxol β-naloxamine, β-naltrexamine and related compounds by the application of the mitsunobu reac". Tetrahedron 50 (32): 9757.  



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