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Title: Netupitant  
Author: World Heritage Encyclopedia
Language: English
Subject: Netupitant/palonosetron, Antiemetics, Cancer and nausea, Azasetron, Ramosetron
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
  • Approved
PubChem CID:
Chemical data
Formula C30H32F6N4O
Molecular mass 578.59 g/mol

Netupitant is an antiemitic drug. In the United States, the combination drug netupitant/palonosetron (Akynzeo) is approved by the Food and Drug Administration for prevention of acute and delayed nausea and vomiting associated with cancer chemotherapy.[1]

Mechanism of action

Netupitant is a selective NK1 receptor antagonist.[2]


  1. ^ "FDA approves Akynzeo for nausea and vomiting associated with cancer chemotherapy".  
  2. ^ Rizzi A, Campi B, Camarda V, Molinari S, Cantoreggi S, Regoli D, Pietra C, Calo G (2012). "In vitro and in vivo pharmacological characterization of the novel NK(1) receptor selective antagonist netupitant". Peptides 37: 86–97.  
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