World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0023832994
Reproduction Date:

Title: Orexigenic  
Author: World Heritage Encyclopedia
Language: English
Subject: Agouti-related peptide, Medroxyprogesterone acetate, Pharmacology, ATC code A15, General anaesthetic
Collection: Drugs, Drugs Acting on the Gastrointestinal System and Metabolism
Publisher: World Heritage Encyclopedia


An orexigenic (OVX), or appetite stimulant, is a drug, hormone, or compound that increases appetite. This can be a naturally occurring neuropeptide hormone such as ghrelin, orexin or neuropeptide Y,[1][2] or a medication which increases hunger and therefore enhances food consumption. Usually appetite enhancement is considered an undesirable side effect of certain drugs as it leads to unwanted weight gain,[3][4][5] but sometimes it can be beneficial and a drug may be prescribed solely for this purpose, especially when the patient is suffering from severe appetite loss or muscle wasting due to cystic fibrosis, anorexia, old age, cancer or AIDS.[6][7][8][9][10] There are several widely used drugs which can cause a boost in appetite, including tricyclic antidepressants (TCAs), tetracyclic antidepressants, natural or synthetic cannabinoids, first-generation antihistamines, most antipsychotics and many steroid hormones.

Agents with orexigenic effects include the following:

See also


  1. ^ Diepvens K, Häberer D, Westerterp-Plantenga M. Different proteins and biopeptides differently affect satiety and anorexigenic/orexigenic hormones in healthy humans.Int J Obes (Lond). 2008 Mar;32(3):510-8. Epub 2007 Nov 27.PMID 18345020
  2. ^ Akimoto S, Miyasaka K (July 2010). "Age-associated changes of hunger-regulating peptides". Geriatrics & Gerontology International. 10 Suppl 1: S107–19.  
  3. ^ Purnell JQ, Weyer C (2003). "Weight effect of current and experimental drugs for diabetes mellitus: from promotion to alleviation of obesity". Treatments in Endocrinology 2 (1): 33–47.  
  4. ^ Hermansen K, Mortensen LS (2007). "Bodyweight changes associated with antihyperglycaemic agents in type 2 diabetes mellitus". Drug Safety : an International Journal of Medical Toxicology and Drug Experience 30 (12): 1127–42.  
  5. ^ Maayan L, Correll CU (July 2010). "Management of antipsychotic-related weight gain". Expert Review of Neurotherapeutics 10 (7): 1175–200.  
  6. ^ Strasser F, Bruera ED (June 2002). "Update on anorexia and cachexia". Hematology/oncology Clinics of North America 16 (3): 589–617.  
  7. ^ Nasr SZ, Drury D (March 2008). "use in cystic fibrosis". Pediatric Pulmonology 43 (3): 209–19.  
  8. ^ Morley JE (2007). "Weight loss in older persons: new therapeutic approaches". Current Pharmaceutical Design 13 (35): 3637–47.  
  9. ^ Fox CB, Treadway AK, Blaszczyk AT, Sleeper RB (April 2009). "Megestrol acetate and mirtazapine for the treatment of unplanned weight loss in the elderly". Pharmacotherapy 29 (4): 383–97.  
  10. ^ Holmes S (July 2009). "A difficult clinical problem: diagnosis, impact and clinical management of cachexia in palliative care". International Journal of Palliative Nursing 15 (7): 320, 322–6.  
  11. ^ LYRICA® (pregabalin), CV. Full Prescribing Information, Section 5.7 (Weight Gain). Pfizer, Inc. Revised June, 2013. [1]
  12. ^

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.