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Periciazine

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Title: Periciazine  
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Subject: Butaclamol, Gevotroline, Promazine, Triflupromazine, Mosapramine
Collection: Alcohols, Nitriles, Phenothiazines, Piperidines
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Periciazine

Periciazine
Systematic (IUPAC) name
10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile
Clinical data
Pregnancy
category
  • AU: C
Legal status
Routes of
administration
Oral
Pharmacokinetic data
Metabolism Hepatic (mostly via conjugation)[1]
Biological half-life 12 h[1]
Excretion Renal[1]
Identifiers
CAS Registry Number  YesY
ATC code N05
PubChem CID:
DrugBank  N
ChemSpider  N
UNII  YesY
KEGG  YesY
ChEBI  N
ChEMBL  N
Chemical data
Formula C21H23N3OS
Molecular mass 365.49 g/mol
 N   

Periciazine (INN), also known as pericyazine (BAN) or propericiazine, is a drug that belongs to the phenothiazine class of typical antipsychotics.

Pericyazine is not approved for sale in the United States. It is commonly sold in Canada under the tradename Neuleptil and in United Kingdom and Australia under the tradename Neulactil.[2]

Contents

  • Medical Uses 1
  • Adverse effects 2
  • References 3
  • External links 4

Medical Uses

The primary uses of pericyazine include in the short-term treatment of severe anxiety or tension and in the maintenance treatment of psychotic disorders such as schizophrenia. There is insufficient evidence to determine whether periciazine is more or less effective than other antipsychotics.[1][3]

Periciazine has also been studied in the treatment of opioid dependence.[4]

Adverse effects

Pericyazine is a rather sedating and anticholinergic antipsychotic, and despite being classed with the typical antipsychotics, its risk of extrapyramidal side effects is comparatively low.[5] It has a relatively high risk of causing hyperprolactinaemia and a moderate risk of causing weight gain and orthostatic hypotension.[5]

References

  1. ^ a b c d
  2. ^
  3. ^ Leucht S, Helfer B, Hartung B. Perazine for schizophrenia. Cochrane Database Syst Rev. 2014 Jan 15;1:CD002832. Review. PMID 24425538
  4. ^
  5. ^ a b

External links


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